(S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone

Base Information

• Chemical Name: (S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone
• CAS No.: 1103917-18-5
• Molecular Formula: C₁₃H₂₂O
• Molecular Weight: 194.317
• Mol file: 1103917-18-5.mol

Synonyms:(S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone

Chemical Property of (S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone

There total 5 articles about (S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

(E)-3-(prop-1-en-1-yl)cyclohex-2-en-1-one (29179-03-1) + isobutylmagnesium bromide (926-62-5) → (S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone (1103917-18-5)

Guidance literature:

(E)-3-(prop-1-en-1-yl)cyclohex-2-en-1-one; isobutylmagnesium bromide; With C₁₈H₂₉N₂O⁽¹⁺⁾*Cl^(1-); copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at -10 ℃; for 1h;

With ammonium chloride; In dichloromethane; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.200803735

Reference yield:

(E)-3-(prop-1-en-1-yl)cyclohex-2-en-1-one (29179-03-1) + isobutylmagnesium bromide (926-62-5) → (S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone (1103917-18-5) + (S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone

Guidance literature:

isobutylmagnesium bromide; With C₁₈H₂₈N₂O⁽¹⁺⁾*Cl^(1-); copper(II) bis(trifluoromethanesulfonate); In diethyl ether; at -10 ℃; for 0.0833333h; Inert atmosphere;

(E)-3-(prop-1-en-1-yl)cyclohex-2-en-1-one; In diethyl ether; at -10 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201200502

Reference yield:

(E)-3-(prop-1-en-1-yl)cyclohex-2-en-1-one (29179-03-1) + isobutylmagnesium bromide (926-62-5) → (S,E)-3-isobutyl-3-(prop-1-enyl)cyclohexanone (1103917-18-5) + C13H22O (1103917-23-2)

Guidance literature:

isobutylmagnesium bromide; With C₁₈H₂₈N₂O⁽¹⁺⁾*Cl^(1-); copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at -10 ℃; for 0.0833333h; Inert atmosphere;

(E)-3-(prop-1-en-1-yl)cyclohex-2-en-1-one; In dichloromethane; at -10 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201200502

upstream raw materials:

(E)-3-(prop-1-en-1-yl)cyclohex-2-en-1-one

isobutylmagnesium bromide

3-Ethoxycyclohex-2-en-1-one