2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate

Base Information

• Chemical Name: 2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate
• CAS No.: 1528459-65-5
• Molecular Formula: C₃₄H₃₈O₁₀S₂
• Molecular Weight: 670.802

Synonyms:2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate

Chemical Property of 2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate

Chemical Property:

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Technology Process of 2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate

There total 5 articles about 2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid (124243-00-1) + O-propargyl triethylene glycol (208827-90-1) → 2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate (1528459-65-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c3cc47003b

Reference yield:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate (1528459-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 22 h / 0 - 20 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3cc47003b

Reference yield:

4-acetyl-benzoic acid (586-89-0) → 2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl 4-[3-tosyl-2-(tosylmethyl) propanoyl]benzoate (1528459-65-5)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol

2: piperidine / ethanol; water; methanol

3: Oxone / water; methanol / 24 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

With piperidine; dmap; Oxone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; dichloromethane; water;

DOI:10.1039/c3cc47003b

upstream raw materials:

4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid

O-propargyl triethylene glycol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

4-acetyl-benzoic acid

Downstream raw materials:

C₂₇H₃₀O₈S

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