(R)-1-BOC-3-FLUORO PYRROLIDINE

Base Information

• Chemical Name: (R)-1-BOC-3-FLUORO PYRROLIDINE
• CAS No.: 876617-25-3
• Molecular Formula: C₉H₁₆FNO₂
• Molecular Weight: 189.23
• Hs Code.: 2933998090
• Mol file: 876617-25-3.mol

Synonyms:tert-Butyl (3R)-3-fluoropyrrolidine-1-carboxylate;N-t-Boc-(3R)-fluoropyrrolidine;

Chemical Property of (R)-1-BOC-3-FLUORO PYRROLIDINE

Chemical Property:

• Vapor Pressure: 0.0659mmHg at 25°C
• Refractive Index: 1.455
• Boiling Point: 230.4 °C at 760 mmHg
• Flash Point: 93.2 °C
• PSA: 29.54000
• Density: 1.08 g/cm³
• LogP: 1.90320
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

(R)-1-Boc-3-Fluoropyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-BOC-3-FLUORO PYRROLIDINE

There total 3 articles about (R)-1-BOC-3-FLUORO PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.77%

(S)-3-(toluene-4-sulfonyloxy)pyrrolidin-1-ylcarboxylic acid tert-butyl ester (371240-55-0) → (R)-1-N-tert-butoxycarbonyl-3-fluoropyrrolidine (876617-25-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Inert atmosphere; Reflux;

Reference yield:

(S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (101469-92-5,83220-73-9) → (R)-1-N-tert-butoxycarbonyl-3-fluoropyrrolidine (876617-25-3)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

→ (R)-1-N-tert-butoxycarbonyl-3-fluoropyrrolidine (876617-25-3)

Guidance literature:

upstream raw materials:

(S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

(S)-3-(toluene-4-sulfonyloxy)pyrrolidin-1-ylcarboxylic acid tert-butyl ester

Downstream raw materials:

(3R)-3-fluoropyrrolidine hydrochloride

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