371240-55-0

Basic information

• Product Name: (S)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (S)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester;(S)-tert-butyl 3-(tosyloxy)pyrrolidine-1-carboxylate
• CAS NO: 371240-55-0
• Molecular Formula: C16H23NO5S
• Molecular Weight: 341.42252
• Mol File: 371240-55-0.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 461.9±38.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: -3.58±0.40(Predicted)
• CAS DataBase Reference: (S)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(371240-55-0)
• EPA Substance Registry System: (S)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(371240-55-0)

Safety Data

• Hazardous Substances Data: 371240-55-0(Hazardous Substances Data)

Usage

General Description

The chemical (S)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester, also known as (S)-4-((tert-butoxycarbonyl)amino)-1-((4-methylphenyl)sulfonyloxy)pyrrolidine, is a compound with potential therapeutic applications in the field of pharmaceuticals. It is a pyrrolidine derivative with a tosylate ester functional group and a tert-butyl ester moiety. (S)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester is believed to have bioactive properties that may be useful in the development of pharmaceutical drugs targeting specific biological pathways. Its chemical structure makes it a potential candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 960508-05-8 2-fluoro-1,3-dimethylimidazolinium p-toluenesulfonate 
• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 

Downstream Products

• 876617-25-3 (R)-1-N-tert-butoxycarbonyl-3-fluoropyrrolidine 
• 133099-11-3 (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetonitrile 
• 143700-04-3 (R)-tert-butyl 3-azidopyrrolidine-1-carboxylate 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 125552-56-9 (S)-tert-butyl 3-azidopyrrolidine-1-carboxylate 
• 188790-89-8 (R)-3-Diphenylphosphanyl-pyrrolidine 
• 188790-91-2 (S)-3-Diphenylphosphanyl-pyrrolidine 

Relevant articles and documents

Synthesis of Arylethylamines via C(sp3)-C(sp3) Palladium-Catalyzed Cross-Coupling

Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds via a palladium-catalyzed C(sp3)-C(sp3) coupling between (chloromethyl)aryls and air-/moisture-stable N,N-dialkylaminomethyltrifluoroborate salts. Rapid hit identification was achieved using microscale high-throughput experimentation and was followed by millimolar-scale reaction parameter optimization. A range of structurally and electronically varied arylethylamine products were obtained in moderate to excellent yields (27-96%, >60 examples). The reaction mechanism is proposed to proceed via formation of a trialkylbenzylammonium species prior to oxidative addition.

MONOCARBOXYLIC ACID TRANSPORTER 4 (MCT4) MODULATORS AND USES THEREOF

Disclosed herein are compounds, compositions, and methods for modulating the monocarboxylic acid transporter 4 (MCT4) with the compounds and compositions disclosed herein. Also described are methods of treating diseases or conditions that are mediated by

Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyl iodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective.