(R,S)-FMOC-ALPHA-METHOXYGLYCINE

Base Information

• Chemical Name: (R,S)-FMOC-ALPHA-METHOXYGLYCINE
• CAS No.: 156059-09-5
• Molecular Formula: C₁₈H₁₇NO₅
• Molecular Weight: 327.337
• Hs Code.: 2924299090
• Mol file: 156059-09-5.mol

Synonyms:Aceticacid, [[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methoxy-, (?à)-; N-9-Fluorenylmethoxycarbonyl-DL-a-methoxyglycine

Chemical Property of (R,S)-FMOC-ALPHA-METHOXYGLYCINE

Chemical Property:

• Boiling Point: 571.6±45.0 °C(Predicted)
• PKA: 2?+-.0.10(Predicted)
• PSA: 84.86000
• Density: 1.314±0.06 g/cm3(Predicted)
• LogP: 2.97310
• Storage Temp.: Store at?0-5°C

Purity/Quality:

98%min ^*data from raw suppliers

(RS)-Fmoc-alpha-methoxyglycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,S)-FMOC-ALPHA-METHOXYGLYCINE

There total 3 articles about (R,S)-FMOC-ALPHA-METHOXYGLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(9H-fluoren-9-ylmethoxycarbonylamino)]methoxyacetic acid methyl ester (475106-70-8) → [(9H-Fluoren-9-ylmethoxycarbonylamino)]-methoxy-acetic acid (156059-09-5)

Guidance literature:

With lithium hydroxide; In water; acetone; Yield given;

DOI:10.1016/S0040-4039(00)75818-7

Reference yield:

9-fluorenylmethyl carbamate (84418-43-9) → [(9H-Fluoren-9-ylmethoxycarbonylamino)]-methoxy-acetic acid (156059-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / ethyl acetate / 6 h / Heating

2: H₂SO₄

3: LiOH / H₂O; acetone

With lithium hydroxide; sulfuric acid; In water; ethyl acetate; acetone;

DOI:10.1016/S0040-4039(00)75818-7

Reference yield:

9-fluorenylmethoxycarbonyl-α-hydroxyglycine (176638-02-1) → [(9H-Fluoren-9-ylmethoxycarbonylamino)]-methoxy-acetic acid (156059-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

2: LiOH / H₂O; acetone

With lithium hydroxide; sulfuric acid; In water; acetone;

DOI:10.1016/S0040-4039(00)75818-7

upstream raw materials:

[(9H-fluoren-9-ylmethoxycarbonylamino)]methoxyacetic acid methyl ester

9-fluorenylmethyl carbamate

9-fluorenylmethoxycarbonyl-α-hydroxyglycine

Refernces