84418-43-9Relevant articles and documents
A convenient, large-scale preparation of a differential protected α-aminoglycine suitable for the synthesis of α-aminoglycine-containing peptides
Rene, Loic,Badet, Bernard
, p. 3237 - 3239 (1996)
α-Boc-amino-Fmoc glycine 6 was prepared in two steps from 9-fluorenylmethylcarbamate 1, glyoxylic acid 3 and t-butyl carbamate 5. This compound is useful in Solid Phase Peptide Synthesis to prepare α-aminoglycine-containing peptides using Fmoc-strategy.
Activation of Fmoc-protected N, O-acetals using trimethylsilyl halides: Mechanistic and synthetic studies
Boaz, Nicholas C.,Bair, Nathaniel C.,Le, Thanh T.,Peelen, Timothy J.
body text, p. 2464 - 2467 (2010/08/07)
Trimethylsilyl halide activation of Fmoc-protected N,O-acetals yields reactive intermediates capable of efficiently adding to a variety of enamines. NMR studies have provided evidence that a stable halomethyl carbamate intermediate forms in solution. Good yields are obtained over a broad range of enamine nucleophiles encompassing both cyclic and acyclic ketone-derived and aldehyde-derived enamines. Preliminary studies suggest that the enamine additions occur through a concerted, SN2-type mechanism.
Compounds for targeting endothelial cells, compositions containing the same and methods for their use
-
, (2008/06/13)
The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
