tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1531605-26-1
Molecular Formula:C₃₆H₄₇NO₅Si
Molecular Weight:601.858
Hs Code.:

Synonyms:tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 5 articles about tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 913253-34-6
{[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane

: 127119-08-8
3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

: 1531605-26-1
tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: 3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; pentane; at -40 ℃; for 0.666667h; Inert atmosphere;

{[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane; In tetrahydrofuran; pentane; at 0 - 20 ℃; for 4.5h; Inert atmosphere;
DOI:10.1039/c3cc48189a

Reference yield:

: 177606-51-8
2-<(tert-butyldiphenylsilyloxy)methyl>prop-2-en-1-ol

: 1531605-26-1
tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 3 h / -60 - -20 °C / Inert atmosphere

2.1: tert.-butyl lithium; N,N,N,N,-tetramethylethylenediamine / pentane; tetrahydrofuran / 0.67 h / -40 °C / Inert atmosphere

2.2: 4.5 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; triphenylphosphine; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1039/c3cc48189a

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1531605-26-1
tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: tert.-butyl lithium; N,N,N,N,-tetramethylethylenediamine / pentane; tetrahydrofuran / 0.67 h / -40 °C / Inert atmosphere

2.2: 4.5 h / 0 - 20 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; triethylamine; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1039/c3cc48189a