{[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane

Base Information

• Chemical Name: {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane
• CAS No.: 913253-34-6
• Molecular Formula: C₂₀H₂₅BrOSi
• Molecular Weight: 389.407
• Mol file: 913253-34-6.mol

Synonyms:{[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane

Chemical Property of {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane

There total 3 articles about {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-<(tert-butyldiphenylsilyloxy)methyl>prop-2-en-1-ol (177606-51-8) → {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane (913253-34-6)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1055/s-2007-983785

Reference yield: 95.0%

2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl methanesulfonate (913253-38-0) → {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane (913253-34-6)

Guidance literature:

With lithium bromide; In diethyl ether; at 20 ℃; for 22h;

DOI:10.1002/ejoc.200600414

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane (913253-34-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 1.17 h / 20 °C

1.2: 98 percent / tetrahydrofuran / 16 h / 20 °C

2.1: 100 percent / triethylamine; DMAP / CH₂Cl₂ / 2.25 h / 20 °C

3.1: 95 percent / LiBr / diethyl ether / 22 h / 20 °C

With dmap; sodium hydride; triethylamine; lithium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.200600414

upstream raw materials:

2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl methanesulfonate

2-<(tert-butyldiphenylsilyloxy)methyl>prop-2-en-1-ol

tert-butylchlorodiphenylsilane

Downstream raw materials:

(S)-3-{(2R,5R)-2-[2-(tert-butyldiphenylsilyloxymethyl)allyl]-5-methylhept-6-enoyl}-4-isopropyloxazolidin-2-one

benzyl (S)-2-benzyloxycarbonylamino-5-tert-butyldiphenylsilyloxymethyl-5-hexenoate

7-{2''-[(tert-butyldiphenylsiloxy)methyl]allyloxy}-6-allyl-5-hydroxy-2-methyl-4H-chromen-4-one

7-{2''-[(tert-butyldiphenylsiloxy)methyl]allyloxy}-8-allyl-5-hydroxy-2-methyl-4H-chromen-4-one