2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile

Base Information

Chemical Name:2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile
CAS No.:1028301-15-6
Molecular Formula:C₃₀H₂₄N₂O₃
Molecular Weight:460.532
Hs Code.:

Synonyms:2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile

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Chemical Property of 2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile

Chemical Property:

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Technology Process of 2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile

There total 3 articles about 2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21968-49-0
2-benzoyl-1-cyano-7,8-dimethoxy-1,2-dihydroisoquinoline

: 939-26-4
2-bromomethylnaphthyl bromide

: 1028301-15-6
2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at -10 ℃; for 4h;
DOI:10.1021/jm0607395

Reference yield:

: 16503-95-0
7,8-dimethoxyisoquinoline

: 1028301-15-6
2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum chloride / CH₂Cl₂ / 20 °C

1.2: 88 percent / CH₂Cl₂ / 20 - 30 °C

2.1: sodium hydride / dimethylformamide / 4 h / -10 °C

With aluminium trichloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0607395

Reference yield:

: 98-88-4
benzoyl chloride

: 1028301-15-6
2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum chloride / CH₂Cl₂ / 20 °C

1.2: 88 percent / CH₂Cl₂ / 20 - 30 °C

2.1: sodium hydride / dimethylformamide / 4 h / -10 °C

With aluminium trichloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0607395