(E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene

Base Information

Chemical Name:(E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene
CAS No.:1374647-36-5
Molecular Formula:C₁₁H₁₃Br
Molecular Weight:225.128
Hs Code.:

Synonyms:(E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene

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Chemical Property of (E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene

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Technology Process of (E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene

There total 4 articles about (E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1174270-30-4
(E)-3-(o-tolyl)but-2-en-1-ol

: 1374647-36-5
(E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene

Guidance literature:: With phosphorus tribromide; In diethyl ether; at -20 ℃; Inert atmosphere;
DOI:10.1002/anie.201107840

Reference yield:

: 577-16-2,122382-54-1
2-Methylacetophenone

: 1374647-36-5
(E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / -78 °C / Inert atmosphere

3.1: phosphorus tribromide / diethyl ether / -20 °C / Inert atmosphere

With phosphorus tribromide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Horner-Wadsworth-Emmonds olefination;
DOI:10.1002/anie.201107840

Reference yield:

: 100994-06-7
EtO₂CCHC(Me)(o-MeC₆H₄)

: 1374647-36-5
(E)-1-(4-bromobut-2-en-2-yl)-2-methylbenzene

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 15 h / 0 - 20 °C / Inert atmosphere

2: phosphorus tribromide / diethyl ether / 0.17 h / 0 °C / Schlenk technique; Inert atmosphere

With lithium aluminium tetrahydride; phosphorus tribromide; In diethyl ether;
DOI:10.1021/acs.orglett.8b00360