ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

Base Information

• Chemical Name: ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate
• CAS No.: 118018-39-6
• Molecular Formula: C₂₆H₂₃ClN₄O₄
• Molecular Weight: 490.946

Synonyms:ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

Chemical Property of ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

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Technology Process of ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

There total 4 articles about ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

p-chlorphenylisocyanate (104-12-1) + ethyl 3(R,S)-amino-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate formate salt → ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate (118018-39-6)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00078a018

Reference yield:

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate (108895-98-3) → ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate (118018-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2 h, 2.) DMF, from 0 deg C to RT, 1 h

2: 100 percent / 10percent Pd/C / methanol / 1.5 h

3: 76 percent / tetrahydrofuran / Ambient temperature

With sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00078a018

Reference yield:

p-chlorphenylisocyanate (104-12-1) + (3RS)-3-amino-1-ethoxycarbonylmethyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one → ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate (118018-39-6)

Guidance literature:

In tetrahydrofuran; P₂ O₅;

upstream raw materials:

p-chlorphenylisocyanate

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

Downstream raw materials:

3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

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