Carbamic acid, (2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, (2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, phenylmethyl ester
• CAS No.: 108895-98-3
• Molecular Formula: C23H19N3O3
• Molecular Weight: 385.422
• Mol file: 108895-98-3.mol

Synonyms:.1,3-Dihydro-5-phenyl-3-benzyloxycarbonylamino-2H-1,4-benzodiazepin-2-one;.3-benzyloxycarbonylamino-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;.(RS)-3-<(benzyloxycarbonyl)amino>-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one;.1,3-dihydro-5-phenyl-3(R,S)-<(benzyloxycarbonyl)amino>-2H-1,4-benzodiazepin-2-one;3-[(benzyloxycarbonyl)amino]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;.1,3-dihydro-5-phenyl-3(R,S)-<(benzyloxycarbonyl)-amino>-2H-1,4-benzodiazepin-2-one;

Chemical Property of Carbamic acid, (2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, phenylmethyl ester

Chemical Property:

• PSA: 79.79000
• LogP: 3.69310

Purity/Quality:

NLT 98% ^*data from raw suppliers

Z-(R,S)-3-Amino-2-oxo-5-phenyl-1,4-benzodiazepine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, phenylmethyl ester

There total 14 articles about Carbamic acid, (2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-α-(benzyloxycarbonyl)glycinyl)amino>benzophenone (108895-97-2) → benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate (108895-98-3)

Guidance literature:

With ammonium acetate; In acetic acid; at 23 ℃; for 12h;

DOI:10.1016/S0040-4039(00)95879-9

Reference yield: 71.0%

benzyl N-[[(2-benzoylphenyl)carbamoyl](1H-1,2,3-benzotriazol-1-yl)methyl]carbamate (161365-74-8) → benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate (108895-98-3)

Guidance literature:

benzyl N-[[(2-benzoylphenyl)carbamoyl](1H-1,2,3-benzotriazol-1-yl)methyl]carbamate; With ammonia; In ethanol; at 20 ℃; for 3h;

With ammonium acetate; acetic acid; at 20 ℃;

DOI:10.1016/j.bmcl.2011.08.101

Reference yield:

2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine (124676-19-3) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate (108895-98-3)

Guidance literature:

2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine; With oxalyl dichloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; at 0 ℃; for 2h;

(2-aminophenyl)(phenyl)methanone; With 4-methyl-morpholine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; at 0 - 20 ℃; for 0.5h;

With sodium hydroxide; ammonium acetate; ammonia; acetic acid; more than 3 stages;

upstream raw materials:

2-α-(benzyloxycarbonyl)glycinyl)amino>benzophenone

benzyl N-[[(2-benzoylphenyl)carbamoyl](1H-1,2,3-benzotriazol-1-yl)methyl]carbamate

O-benzyl carbamate

2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine

Downstream raw materials:

[1-(2-Hydroxy-ethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

2,3-Dihydro-2-oxo-5-phenyl-3-(((phenylmethoxy)carbonyl)amino)-1H-1,4-benzodiazepine-1-propanoic acid ethyl ester

1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

{1-[1-(2,4-Dinitro-phenyl)-1H-imidazol-2-ylmethyl]-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl}-carbamic acid benzyl ester