benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

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Chemical Name:benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester
CAS No.:192698-58-1
Molecular Formula:C₆₃H₅₉BrO₁₂
Molecular Weight:1088.06
Hs Code.:

benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

Synonyms:benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

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Chemical Property of benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

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Technology Process of benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

There total 20 articles about benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 192698-57-0
benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(hydroxymethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

: 192698-58-1
benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In tetrahydrofuran; 10 deg C to rt;
DOI:10.1021/jo970596h

Reference yield:

: 147067-72-9
Benzoic acid 3-formyl-4-(2-methoxy-ethoxymethoxy)-phenyl ester

: 192698-58-1
benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / NaBH₄ / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 0.33 h / -78 - -45 °C

2: 89 percent / Ph₃P, NBS / tetrahydrofuran / 0.25 h / 5 °C

3: 87 percent / 1.) Zn, 1,2-dibromoethane, 2.) (Ph₃P)4Pd / tetrahydrofuran / 1.) -5 deg C, 4.75 h, 2.) 60 deg C, 17 h

4: 95 percent / AcOH, Bu₄NF / tetrahydrofuran / 1 h

5: 97 percent / Ph₃P, NBS / tetrahydrofuran / 10 deg C to rt

6: 83 percent / 1.) Zn, 1,2-dibromoethane, 2.) (Ph₃P)4Pd / tetrahydrofuran

7: 83 percent / AcOH, Bu₄NF / tetrahydrofuran / 1 h

8: 96 percent / Ph₃P, NBS / tetrahydrofuran / 10 deg C to rt

With sodium tetrahydroborate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; acetic acid; ethylene dibromide; triphenylphosphine; zinc; In tetrahydrofuran; diethylene glycol dimethyl ether;
DOI:10.1021/jo970596h

Reference yield:

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 192698-58-1
benzoic acid 3-(5-(benzyloxy)-3-{5-(benzoyloxy)-3-[5-(benzyloxy)-3-(bromomethyl)-2-methoxybenzyl]-2-methoxybenzyl}-2-methoxybenzyl)-4-[(2-methoxyethoxy)methoxy]phenyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 5 h

2: NaH, DMPU / tetrahydrofuran / -10 deg C, 45 min, -10 deg C to rt, 4 h

3: 84 percent / NaBH₄ / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 0.33 h / -78 - -45 °C

4: 89 percent / Ph₃P, NBS / tetrahydrofuran / 0.25 h / 5 °C

5: 87 percent / 1.) Zn, 1,2-dibromoethane, 2.) (Ph₃P)4Pd / tetrahydrofuran / 1.) -5 deg C, 4.75 h, 2.) 60 deg C, 17 h

6: 95 percent / AcOH, Bu₄NF / tetrahydrofuran / 1 h

7: 97 percent / Ph₃P, NBS / tetrahydrofuran / 10 deg C to rt

8: 83 percent / 1.) Zn, 1,2-dibromoethane, 2.) (Ph₃P)4Pd / tetrahydrofuran

9: 83 percent / AcOH, Bu₄NF / tetrahydrofuran / 1 h

10: 96 percent / Ph₃P, NBS / tetrahydrofuran / 10 deg C to rt

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; ethylene dibromide; triethylamine; triphenylphosphine; zinc; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1021/jo970596h