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1194-98-5 Usage


2,5-Dihydroxybenzaldehyde, with the CAS number 1194-98-5, is a building block compound that serves as a crucial intermediate in organic synthesis. It is characterized by the presence of hydroxy groups at positions 2 and 5 on a benzaldehyde structure, as defined by ChEBI. This yellow to khaki-green crystalline powder has been utilized in the synthesis of various organic compounds, including 2,4-dimethylbenzoylhydrazones, which exhibit antileishmanial and antioxidant properties.


Used in Organic Synthesis:
2,5-Dihydroxybenzaldehyde is used as a key building block in organic synthesis for the creation of a wide range of chemical compounds. Its unique structure allows it to be a versatile component in the formation of various organic molecules, contributing to the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,5-Dihydroxybenzaldehyde is used as a starting material for the synthesis of drugs with potential therapeutic applications. Its ability to form 2,4-dimethylbenzoylhydrazones, which have demonstrated antileishmanial and antioxidant activity, highlights its potential in developing treatments for diseases like leishmaniasis and in providing antioxidant therapies.
Used in Chemical Research:
2,5-Dihydroxybenzaldehyde is also utilized in chemical research as a model compound to study various chemical reactions and mechanisms. Its reactivity and structural features make it an ideal candidate for understanding reaction pathways and optimizing synthetic routes in the development of new chemical entities.


Add 80 mmol of dry paraformaldehyde to a mixture of 12 mmol of the phenol derivative and 2.5 mmol of MgO nanocrystalline (0.1 g). Expose the resulting mixture under microwave irradiation with a power of 650 W. Monitor the progress of the reaction by thin layer chromatography (TLC) developed by n-hexane : ethyl acetate (8 : 2). Add 100 mL of sulfuric acid (15% w/w) to the reaction mixture and heated at 50 °C for 15 min. Cool the reaction mixture to room temperature. Extract the product by dichloromethane (2 x 50 mL). Dry the organic layer over anhydrous magnesium sulphate. Evaporate the solution resulting from filtration to obtain the crude product. Purify the other product by column chromatography using n-hexane : ethyl acetate (95 : 5 to 70 : 30).

Check Digit Verification of cas no

The CAS Registry Mumber 1194-98-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1194-98:
85 % 10 = 5
So 1194-98-5 is a valid CAS Registry Number.

1194-98-5 Well-known Company Product Price

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  • Alfa Aesar

  • (A15565)  2,5-Dihydroxybenzaldehyde, 98+%   

  • 1194-98-5

  • 1g

  • 334.0CNY

  • Detail
  • Alfa Aesar

  • (A15565)  2,5-Dihydroxybenzaldehyde, 98+%   

  • 1194-98-5

  • 5g

  • 592.0CNY

  • Detail
  • Alfa Aesar

  • (A15565)  2,5-Dihydroxybenzaldehyde, 98+%   

  • 1194-98-5

  • 25g

  • 2455.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name 2,5-dihydroxybenzaldehyde

1.2 Other means of identification

Product number -
Other names 2,5-dihydroxybenzylaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1194-98-5 SDS

1194-98-5Relevant articles and documents

Access to functionalized quinones via the aromatic oxidation of phenols bearing an alcohol or olefinic function catalyzed by supported iron phthalocyanine

Zalomaeva, Olga V.,Sorokin, Alexander B.

, p. 1768 - 1773 (2006)

The controlled oxidation at only one position of compounds with several oxidizable sites, while keeping the other sites intact, has been demonstrated for phenols bearing alcohol or olefinic functional groups. Iron tetrasulfophthalocyanine supported on silica was found to be an efficient catalyst for the preparation of functionalized quinones under mild conditions, with tert-butylhydroperoxide as the oxidant. A novel rapid and mild one-pot procedure for the covalent grafting of iron tetrasulfophthalocyanine onto silica has been developed. The supported catalyst was characterized by chemical analysis, a specific surface study, UV-vis spectroscopy and XPS. A non-radical mechanism for this unusual selective oxidation has been revealed by 18O labelling experiments. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Ulrich et al.

, p. 2437,2438 (1974)


Rao et al.

, p. 2548 (1975)



, p. 281,283 (1974)


Balci, Metin,Suetbeyaz, Yasar

, p. 311 - 314 (1983)

Bicyclic endoperoxides with strained and perturbed diene moiety have been submitted to CoTPP-catalyzed rearrangement.Side reaction, like formation of epoxyenone, has been suppressed and yield of the formation of bisepoxides highly increased.

Preparation method of 2, 5-dihydroxy benzaldehyde


Paragraph 0017; 0020-0022; 0025-0026, (2021/07/17)

The invention discloses a preparation method of 2, 5-dihydroxy benzaldehyde, which is used for preparing an important intermediate of a liquid crystal compound, and relates to the technical field of liquid crystals. The preparation method comprises the steps of by taking p-methoxyphenol as a raw material, alkyl nitrile as a solvent, paraformaldehyde as a formylation reagent and magnesium chloride and triethylamine as catalysts, reacting for 2-4 hours, extracting reaction liquid by using an organic solvent, washing with water, drying, and evaporating to remove the solvent to obtain liquid 2-hydroxy-5-methoxybenzaldehyde, and then by using toluene as a solvent, and enabling the obtained 2-hydroxy-5-methoxybenzaldehyde to be subjected to a demethylation reaction under the action of anhydrous aluminum trichloride to obtain 2, 5-dihydroxy benzaldehyde; and reacting for 2-4 hours, washing the reaction liquid with water, extracting with an organic solvent, drying, evaporating to remove the solvent, and crystallizing the solvent. The method has the advantages of cheap and easily available raw materials, simple operation and convenient industrial production.



Paragraph 0130; 0135, (2020/06/15)

The present invention provides a novel method for producing a 2-hydrazinobenzothiazole derivative. The present invention also provides a method for producing a compound by using the 2-hydrazinobenzothiazole derivative obtained by the production method, and a composition that contains the compound. The present invention also provides a polymerizable composition that is useful in producing film-shaped polymers and contains the compound obtained by the production method. The invention of the present application provides a method for producing a compound represented by general formula (I-C), the method including a step of reacting a compound represented by general formula (I-B) with a compound represented by general formula (I-A) in the presence of at least one compound selected from the group consisting of metal amides, metal hydrides, metal alkoxides, and organic alkali metals. A compound derived from the compound produced by the production method, and a composition that contains the compound are also provided.



Paragraph 0131, (2019/03/08)

The present invention provides a novel method for producing an ester group-containing compound and a derivative produced using the compound as a synthetic intermediate. The invention also provides a polymerizable composition containing the compound obtained by the production method and a film-shaped polymer obtained by polymerizing the polymerizable composition. The present invention is a method for producing an ester group-containing compound, the method including a mixing step of mixing a condensing agent, a Bronsted acid, a carboxylic acid, and a phenol or an alcohol to prepare a reaction mixture. The Bronsted acid selected is other than the condensing agent, the carboxylic acid, and the phenol.

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