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1194-98-5 Usage


2,5-Dihydroxybenzaldehyde is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activity.


Add 80 mmol of dry paraformaldehyde to a mixture of 12 mmol of the phenol derivative and 2.5 mmol of MgO nanocrystalline (0.1 g). Expose the resulting mixture under microwave irradiation with a power of 650 W. Monitor the progress of the reaction by thin layer chromatography (TLC) developed by n-hexane : ethyl acetate (8 : 2). Add 100 mL of sulfuric acid (15% w/w) to the reaction mixture and heated at 50 °C for 15 min. Cool the reaction mixture to room temperature. Extract the product by dichloromethane (2 x 50 mL). Dry the organic layer over anhydrous magnesium sulphate. Evaporate the solution resulting from filtration to obtain the crude product. Purify the other product by column chromatography using n-hexane : ethyl acetate (95 : 5 to 70 : 30).

Chemical Properties

yellow to khaki-green crystalline powder


2,5-Dihydroxybenzaldehyde (cas# 1194-98-5) is a compound useful in organic synthesis.


ChEBI: A dihydroxybenzaldehyde carrying hydroxy groups at positions 2 and 5.

Check Digit Verification of cas no

The CAS Registry Mumber 1194-98-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1194-98:
85 % 10 = 5
So 1194-98-5 is a valid CAS Registry Number.

1194-98-5 Well-known Company Product Price

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  • Alfa Aesar

  • (A15565)  2,5-Dihydroxybenzaldehyde, 98+%   

  • 1194-98-5

  • 1g

  • 334.0CNY

  • Detail
  • Alfa Aesar

  • (A15565)  2,5-Dihydroxybenzaldehyde, 98+%   

  • 1194-98-5

  • 5g

  • 592.0CNY

  • Detail
  • Alfa Aesar

  • (A15565)  2,5-Dihydroxybenzaldehyde, 98+%   

  • 1194-98-5

  • 25g

  • 2455.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name 2,5-dihydroxybenzaldehyde

1.2 Other means of identification

Product number -
Other names 2,5-dihydroxybenzylaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1194-98-5 SDS

1194-98-5Relevant articles and documents

Access to functionalized quinones via the aromatic oxidation of phenols bearing an alcohol or olefinic function catalyzed by supported iron phthalocyanine

Zalomaeva, Olga V.,Sorokin, Alexander B.

, p. 1768 - 1773 (2006)

The controlled oxidation at only one position of compounds with several oxidizable sites, while keeping the other sites intact, has been demonstrated for phenols bearing alcohol or olefinic functional groups. Iron tetrasulfophthalocyanine supported on silica was found to be an efficient catalyst for the preparation of functionalized quinones under mild conditions, with tert-butylhydroperoxide as the oxidant. A novel rapid and mild one-pot procedure for the covalent grafting of iron tetrasulfophthalocyanine onto silica has been developed. The supported catalyst was characterized by chemical analysis, a specific surface study, UV-vis spectroscopy and XPS. A non-radical mechanism for this unusual selective oxidation has been revealed by 18O labelling experiments. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Ulrich et al.

, p. 2437,2438 (1974)


Rao et al.

, p. 2548 (1975)



, p. 281,283 (1974)


Balci, Metin,Suetbeyaz, Yasar

, p. 311 - 314 (1983)

Bicyclic endoperoxides with strained and perturbed diene moiety have been submitted to CoTPP-catalyzed rearrangement.Side reaction, like formation of epoxyenone, has been suppressed and yield of the formation of bisepoxides highly increased.

Preparation method of 2, 5-dihydroxy benzaldehyde


Paragraph 0017; 0020-0022; 0025-0026, (2021/07/17)

The invention discloses a preparation method of 2, 5-dihydroxy benzaldehyde, which is used for preparing an important intermediate of a liquid crystal compound, and relates to the technical field of liquid crystals. The preparation method comprises the steps of by taking p-methoxyphenol as a raw material, alkyl nitrile as a solvent, paraformaldehyde as a formylation reagent and magnesium chloride and triethylamine as catalysts, reacting for 2-4 hours, extracting reaction liquid by using an organic solvent, washing with water, drying, and evaporating to remove the solvent to obtain liquid 2-hydroxy-5-methoxybenzaldehyde, and then by using toluene as a solvent, and enabling the obtained 2-hydroxy-5-methoxybenzaldehyde to be subjected to a demethylation reaction under the action of anhydrous aluminum trichloride to obtain 2, 5-dihydroxy benzaldehyde; and reacting for 2-4 hours, washing the reaction liquid with water, extracting with an organic solvent, drying, evaporating to remove the solvent, and crystallizing the solvent. The method has the advantages of cheap and easily available raw materials, simple operation and convenient industrial production.

Substrate-Induced Dimerization Assembly of Chiral Macrocycle Catalysts toward Cooperative Asymmetric Catalysis

Ao, Yu-Fei,Guo, Hao,Meng, Wei,Wang, De-Xian,Wang, Qi-Qiang,Zhang, Lie-Wei,Zhou, Hao

supporting information, p. 2623 - 2627 (2020/02/04)

An artificial system of substrate-induced dimerization assembly of chiral macrocycle catalysts enables a highly cooperative hydrogen-bonding activation network for efficient enantioselective transformation. These macrocycles contain two thiourea and two chiral diamine moieties and dimerize with sulfate to form a sandwich-like assembly. The macrocycles then adopt an extended conformation and reciprocally complement the hydrogen-bonding interaction sites. Inspired by the guest-induced dynamic assembly, these macrocycles catalyze the decarboxylative Mannich reaction of cyclic aldimines containing a sulfamate heading group. The imine substrate can be activated toward nucleophilic attack of β-ketoacid by a cooperative hydrogen-bonding network enabled by sulfamate-induced dimerization assembly of the macrocycle catalysts. Highly efficient (>95 % yield in most cases) and enantioselective (up to 97.5:2.5 er) transformation of a variety of substrates using only 5 mol % macrocycle was achieved.

Preparation method of 2,5-dihydroxybenzaldehyde


, (2019/10/29)

The invention provides a method for synthesizing 2,5-dihydroxybenzaldehyde. The method comprises the following steps: with p-dimethoxybenzene as a raw material, carrying out bromination reaction, Grignard reaction and demethylation reaction to obtain the 2,5-dihydroxybenzaldehyde. The preparation conditions are mild, the process is simple, and the industrial application value is high.

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