N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Base Information

Chemical Name:N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester
CAS No.:101375-08-0
Molecular Formula:C₂₅H₃₁N₇O₅
Molecular Weight:509.565
Hs Code.:

Synonyms:N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Suppliers and Price of N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

There total 24 articles about N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 101348-32-7
2,4-diamino-6-(bromomethyl)-5-methylpyrido<2,3-d>pyrimidine

: 101375-08-0
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: In N,N-dimethyl acetamide; for 72h; Ambient temperature;
DOI:10.1021/jm00155a021

Reference yield: 15.0%

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 101810-73-5
2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carbonitrile

: 101375-08-0
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: With hydrogen; acetic acid; nickel; for 4h; under 760 Torr;
DOI:10.1021/jm00156a029

Reference yield:

: 101348-21-4
5-cyano-1,3-bis(methoxymethyl)-6-methyluracil

: 101375-08-0
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 45.3 percent / NaOEt / ethanol / 2 h / 60 °C

2: 1.) NaNO₂, HCl, 2.) HCl, H₂O / 1.) water, 2.5 h, 2.) 1 h

3: 100 percent / SOCl₂ / CHCl₃; dimethylformamide / Heating

4: 81 percent / MgO, H₂ / 10percent Pd/C / dioxane / 2585.7 Torr

5: 89 percent / H₂ / Raney Ni / acetic acid / 2585.7 Torr

6: 95 percent / NaNO₂, AcOH, Ac₂O / 2 h / Ambient temperature

7: 91 percent / Heating

8: 87 percent / BCl₃ / CH₂Cl₂ / a) -78 deg C, 3 h, b) RT, overnight

9: 93 percent / pyridine / 48 h / Ambient temperature

10: p-TsOH, hexamethyldisilazane, NH₃ / 120 h / 155 - 160 °C

11: 50percent aq. MeOH / 4 h / Heating

12: 100 percent / HBr / dioxane / 20 h

13: 93 percent / N,N-dimethyl-acetamide / 72 h / Ambient temperature

With pyridine; hydrogenchloride; methanol; thionyl chloride; ammonia; water; hydrogen bromide; hydrogen; sodium ethanolate; acetic anhydride; magnesium oxide; boron trichloride; toluene-4-sulfonic acid; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium nitrite; palladium on activated charcoal; nickel; In 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00155a021