5-methyl-5-deazamethotrexate

Base Information

Chemical Name:5-methyl-5-deazamethotrexate
CAS No.:101810-79-1
Molecular Formula:C₂₂H₂₅N₇O₅
Molecular Weight:467.484
Hs Code.:

Synonyms:5-methyl-5-deazamethotrexate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-methyl-5-deazamethotrexate

Chemical Property:

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Technology Process of 5-methyl-5-deazamethotrexate

There total 11 articles about 5-methyl-5-deazamethotrexate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 101810-77-9
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester

: 101810-79-1
5-methyl-5-deazamethotrexate

Guidance literature:: With sodium hydroxide; In methanol; 1.) 22 deg C - 25 deg C, 48 h, 2.) 45 deg C - 50 deg C, 1 h, 3.) 22 deg C - 25 deg C, 17 h;
DOI:10.1021/jm00156a029

Reference yield: 64.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 101348-20-3
N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid

: 101810-79-1
5-methyl-5-deazamethotrexate

Guidance literature:: With sodium hydroxide; sodium cyanoborohydride; at 22 - 25 ℃; for 21h;
DOI:10.1021/jm00156a029

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 101810-79-1
5-methyl-5-deazamethotrexate

Guidance literature:: Multi-step reaction with 3 steps

1: 15 percent / H₂, glacial AcOH / Raney Ni / 4 h / 760 Torr

2: 82 percent / 1 N aq. NaOH / dimethylsulfoxide / 6 h / 20 - 23 °C

3: 64 percent / 1 N aq. NaOH, NaBH₃CN / 21 h / 22 - 25 °C

With sodium hydroxide; hydrogen; sodium cyanoborohydride; acetic acid; nickel; In dimethyl sulfoxide;
DOI:10.1021/jm00156a029