1-(4-FLUORO-PHENYL)-PIPERIDIN-2-ONE

Base Information

• Chemical Name: 1-(4-FLUORO-PHENYL)-PIPERIDIN-2-ONE
• CAS No.: 27471-40-5
• Molecular Formula: C₁₁H₁₂FNO
• Molecular Weight: 193.221
• Mol file: 27471-40-5.mol

Synonyms:2-Piperidone,1-(p-fluorophenyl)- (8CI)

Chemical Property of 1-(4-FLUORO-PHENYL)-PIPERIDIN-2-ONE

Chemical Property:

• Boiling Point: 384.6±25.0 °C(Predicted)
• PKA: 0.61±0.20(Predicted)
• PSA: 20.31000
• Density: 1.189±0.06 g/cm3(Predicted)
• LogP: 2.40760

Purity/Quality:

99% ^*data from raw suppliers

1-(4-FLUORO-PHENYL)PIPERIDIN-2-ONE 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-FLUORO-PHENYL)-PIPERIDIN-2-ONE

There total 1 articles about 1-(4-FLUORO-PHENYL)-PIPERIDIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

piperidin-2-one (675-20-7) + 4-fluoro-1-iodobenzene (352-34-1) → 1-(4-fluorophenyl)piperidin-2-one (27471-40-5)

Guidance literature:

With potassium phosphate; copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.3390/molecules19022655

Reference yield: 82.0%

1-(4-fluorophenyl)piperidin-2-one (27471-40-5) + isobutyl chloroformate (543-27-1) → isobutyl 1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate (1612842-39-3)

Guidance literature:

1-(4-fluorophenyl)piperidin-2-one; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 4h; Inert atmosphere;

isobutyl chloroformate; In tetrahydrofuran; for 0.166667h; Inert atmosphere;

DOI:10.3390/molecules19022655

Reference yield:

1-(4-fluorophenyl)piperidin-2-one (27471-40-5) → 3-chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)phenoxy)picolinamide (1612842-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

1.2: 0.17 h / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 5 h / 0 - 20 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; tert.-butyl lithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water;

DOI:10.3390/molecules19022655

upstream raw materials:

piperidin-2-one

4-fluoro-1-iodobenzene

Downstream raw materials:

3-chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)phenoxy)picolinamide

3-chloro-4-(4-(3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)-2-fluorophenoxy)-picolinamide

N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide

N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide