3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

Base Information

Chemical Name:3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate
CAS No.:1564256-51-4
Molecular Formula:C₁₈H₁₈F₃NO₃S
Molecular Weight:385.407
Hs Code.:

Synonyms:3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

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Chemical Property of 3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

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Technology Process of 3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

There total 1 articles about 3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

: 358-23-6
trifluoromethylsulfonic anhydride

: 109010-52-8
[125I]-SKF 83692

: 1564256-51-4
3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

Guidance literature:: [125I]-SKF 83692; With triethylamine; In dichloromethane; at -78 ℃; for 0.5h;

trifluoromethylsulfonic anhydride; In dichloromethane;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-51-4
3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

: 1564256-53-6
3-methyl-5-phenyl-2,3,4,5-tetrahydro-benzo[d]azepin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; 18-crown-6 ether / tetrahydrofuran / 7 h / Reflux; Inert atmosphere

2: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

With 18-crown-6 ether; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-51-4
3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

: 1564256-50-3
2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; 18-crown-6 ether / tetrahydrofuran / 7 h / Reflux; Inert atmosphere

2: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

3: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With 18-crown-6 ether; (1S)-10-camphorsulfonic acid; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; isopropyl alcohol;
DOI:10.1021/ml400373j