2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1564256-50-3
Molecular Formula:C₂₉H₂₉ClN₆O
Molecular Weight:513.042
Hs Code.:

Synonyms:2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

There total 4 articles about 2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1564256-53-6
3-methyl-5-phenyl-2,3,4,5-tetrahydro-benzo[d]azepin-7-amine

: 1564256-50-3
2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With (1S)-10-camphorsulfonic acid; In isopropyl alcohol; at 80 ℃; for 1h; Microwave irradiation;
DOI:10.1021/ml400373j

Reference yield:

: 109010-52-8
[125I]-SKF 83692

: 1564256-50-3
2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / -78 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; 18-crown-6 ether / tetrahydrofuran / 7 h / Reflux; Inert atmosphere

3: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

4: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With 18-crown-6 ether; (1S)-10-camphorsulfonic acid; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-51-4
3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

: 1564256-50-3
2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; 18-crown-6 ether / tetrahydrofuran / 7 h / Reflux; Inert atmosphere

2: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

3: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With 18-crown-6 ether; (1S)-10-camphorsulfonic acid; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; isopropyl alcohol;
DOI:10.1021/ml400373j