ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate

Base Information

• Chemical Name: ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate
• CAS No.: 114214-48-1
• Molecular Formula: C₁₉H₁₃F₄NO₄
• Molecular Weight: 395.31
• Mol file: 114214-48-1.mol

Synonyms:ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate

Chemical Property of ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate

There total 7 articles about ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-3-(2,4-Difluoro-phenylamino)-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester → ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate (114214-48-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

DOI:10.1016/j.bmcl.2004.03.070

Reference yield:

2,4,5-trifluoro-3-methoxybenzoyl chloride (112811-66-2) → ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate (114214-48-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.88 g / Et₃N / toluene / 5 h / 90 °C

2: ethanol; diethyl ether / 24 h / 20 °C

3: 611 mg / K₂CO₃ / dimethylformamide / 5 h / 100 °C

With potassium carbonate; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2006.07.003

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) → ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate (114214-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; diethyl ether / 3 h / 20 °C

2: potassium carbonate / dimethylformamide / 5 h / 100 °C

With potassium carbonate; In diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.03.070

upstream raw materials:

3-methoxy-2,4,5-trifluorobenzoic acid

2,4,5-trifluoro-3-methoxybenzoyl chloride

2,4-difluorophenylamine

(Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

Downstream raw materials:

1-(2,4-difluorophenyl)-7-[(1α,5α,6α)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

1-(2,4-difluorophenyl)-7-[(1α,5α,6α)-6-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid