(Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

Base Information

• Chemical Name: (Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester
• CAS No.: 722542-90-7
• Molecular Formula: C₁₇H₂₀F₃NO₄
• Molecular Weight: 359.345
• Mol file: 722542-90-7.mol

Synonyms:(Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

Chemical Property of (Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

There total 2 articles about (Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,5-trifluoro-3-methoxybenzoyl chloride (112811-66-2) + ethyl 3-(N,N-diethylamino)acrylate → (Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester (722542-90-7)

Guidance literature:

With triethylamine; In toluene; at 90 ℃; for 5h;

DOI:10.1016/j.bmcl.2004.03.070

Reference yield:

3-methoxy-2,4,5-trifluorobenzoic acid (112811-65-1) → (Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester (722542-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 24 h

2: triethylamine / toluene / 5 h / 90 °C

With oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmc.2012.12.011

Reference yield:

(Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester (722542-90-7) → ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate (112811-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; diethyl ether / 3 h / 20 °C

2: potassium carbonate / dimethylformamide / 5 h / 100 °C

With potassium carbonate; In diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.03.070

upstream raw materials:

2,4,5-trifluoro-3-methoxybenzoyl chloride

3-methoxy-2,4,5-trifluorobenzoic acid

Downstream raw materials:

ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate

1-(2,4-difluorophenyl)-7-[(1α,5α,6α)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid