(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate

Base Information

Chemical Name:(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate
CAS No.:1191280-74-6
Molecular Formula:C₂₆H₃₇NO₃
Molecular Weight:427.458
Hs Code.:

Synonyms:(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate

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Chemical Property of (R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate

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Technology Process of (R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate

There total 7 articles about (R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1191280-71-3
(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol

: 79-30-1
isobutyryl chloride

: 1191280-74-6
(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -30 ℃; for 3h;

Reference yield:

: 628711-07-9
benzyl 4-(benzyloxy)-3-bromobenzoate

: 1191280-74-6
(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium aluminium deuteride / tetrahydrofuran / 12 h / 20 °C

2.1: potassium carbonate / acetone / 5 h

3.1: iodine; magnesium / tetrahydrofuran / 1 h / 80 °C

3.2: 1 h / -30 °C

3.3: -30 - 20 °C

4.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C

4.2: pH 2

5.1: pyridine; thionyl chloride / toluene / 1 h / Reflux

6.1: triethylamine / diethyl ether / 4 h

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 20 °C

8.1: boron trichloride / dichloromethane / 3 h / -78 °C

8.2: 20 °C / pH 9

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -30 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; lithium aluminium deuteride; dihydrogen peroxide; iodine; boron trichloride; potassium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; toluene;

Reference yield:

: 1191280-67-7
(R)-3-(2-(benzyloxy)-5-(benzyloxy(methyl-d2))phenyl)-3-phenylpropanoic acid

: 1191280-74-6
(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenyl isobutyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; thionyl chloride / toluene / 1 h / Reflux

2.1: triethylamine / diethyl ether / 4 h

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 20 °C

4.1: boron trichloride / dichloromethane / 3 h / -78 °C

4.2: 20 °C / pH 9

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -30 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; boron trichloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;