(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol

Base Information

Chemical Name:(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol
CAS No.:1191280-71-3
Molecular Formula:C₂₂H₃₁NO₂
Molecular Weight:357.367
Hs Code.:

Synonyms:(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol

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Chemical Property of (R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol

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Technology Process of (R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol

There total 7 articles about (R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1191280-73-5
(R)-3-(2-(benzyloxy)-5-(benzyloxy(methyl-d2))phenyl)-N,N-di(isopropyl-d7)-3-phenylpropan-1-amine

: 1191280-71-3
(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol

Guidance literature:: (R)-3-(2-(benzyloxy)-5-(benzyloxy(methyl-d2))phenyl)-N,N-di(isopropyl-d7)-3-phenylpropan-1-amine; With boron trichloride; In dichloromethane; at -78 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; pH=9;

Reference yield:

: 628711-07-9
benzyl 4-(benzyloxy)-3-bromobenzoate

: 1191280-71-3
(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium deuteride / tetrahydrofuran / 12 h / 20 °C

2.1: potassium carbonate / acetone / 5 h

3.1: iodine; magnesium / tetrahydrofuran / 1 h / 80 °C

3.2: 1 h / -30 °C

3.3: -30 - 20 °C

4.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C

4.2: pH 2

5.1: pyridine; thionyl chloride / toluene / 1 h / Reflux

6.1: triethylamine / diethyl ether / 4 h

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 20 °C

8.1: boron trichloride / dichloromethane / 3 h / -78 °C

8.2: 20 °C / pH 9

With pyridine; lithium aluminium tetrahydride; thionyl chloride; lithium aluminium deuteride; dihydrogen peroxide; iodine; boron trichloride; potassium carbonate; magnesium; triethylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; toluene;

Reference yield:

: 1191280-67-7
(R)-3-(2-(benzyloxy)-5-(benzyloxy(methyl-d2))phenyl)-3-phenylpropanoic acid

: 1191280-71-3
(R)-2-(3-(di(isopropyl-d7)-amino)-1-phenylpropyl)-4-(hydroxyl(methyl-d2))phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; thionyl chloride / toluene / 1 h / Reflux

2.1: triethylamine / diethyl ether / 4 h

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 20 °C

4.1: boron trichloride / dichloromethane / 3 h / -78 °C

4.2: 20 °C / pH 9

With pyridine; lithium aluminium tetrahydride; thionyl chloride; boron trichloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;