Technology Process of 9,9'-dibenzyl-6'-chloro-[6,8']bipurine
There total 5 articles about 9,9'-dibenzyl-6'-chloro-[6,8']bipurine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
9-benzyl-6-chloro-8-iodo-9H-purine;
With
chloro-trimethyl-silane; ethylene dibromide; zinc;
In
N,N-dimethyl acetamide;
at 20 ℃;
for 0.0416667h;
9-benzyl-6-iodo-9H-purine;
With
tris(dibenzylideneacetone)dipalladium (0);
In
tetrahydrofuran; N,N-dimethyl acetamide;
at 45 ℃;
for 16h;
DOI:10.1002/ejoc.200600724
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 28.0 g / TMSCl; tert-butyl nitrite; benzyltriethylammonium chloride / CH2Cl2 / 27 h / 20 °C
2.1: 88 percent / aq. HI / 1 h / 0 °C
3.1: 1,2-dibromoethane; TMSCl; zinc / N,N-dimethyl-acetamide / 0.04 h / 20 °C
3.2: 61 percent / Pd2(dba)3; tfp / tetrahydrofuran; N,N-dimethyl-acetamide / 16 h / 45 °C
With
chloro-trimethyl-silane; tert.-butylnitrite; N-benzyl-N,N,N-triethylammonium chloride; hydrogen iodide; ethylene dibromide; zinc;
In
dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/ejoc.200600724
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 88 percent / aq. HI / 1 h / 0 °C
2.1: 1,2-dibromoethane; TMSCl; zinc / N,N-dimethyl-acetamide / 0.04 h / 20 °C
2.2: 61 percent / Pd2(dba)3; tfp / tetrahydrofuran; N,N-dimethyl-acetamide / 16 h / 45 °C
With
chloro-trimethyl-silane; hydrogen iodide; ethylene dibromide; zinc;
In
N,N-dimethyl acetamide;
DOI:10.1002/ejoc.200600724
