Technology Process of 9,9',9'',9'''-tetrabenzyl-6'''-chloro-[6,8',6',8'',6''.8''']quaterpurine
There total 10 articles about 9,9',9'',9'''-tetrabenzyl-6'''-chloro-[6,8',6',8'',6''.8''']quaterpurine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
9-benzyl-6-chloro-8-iodo-9H-purine;
With
isopropylmagnesium chloride lithium chloride complex;
In
tetrahydrofuran;
at -40 ℃;
for 0.25h;
With
zinc dibromide;
In
tetrahydrofuran;
at -40 - 20 ℃;
9,9',9''-tribenzyl-6''-iodo-[6,8',6',8'']terpurine;
With
tris(dibenzylideneacetone)dipalladium (0);
In
tetrahydrofuran;
at 45 ℃;
for 16h;
DOI:10.1002/ejoc.200600724
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 28.0 g / TMSCl; tert-butyl nitrite; benzyltriethylammonium chloride / CH2Cl2 / 27 h / 20 °C
2.1: 88 percent / aq. HI / 1 h / 0 °C
3.1: 1,2-dibromoethane; TMSCl; zinc / N,N-dimethyl-acetamide / 0.04 h / 20 °C
3.2: 61 percent / Pd2(dba)3; tfp / tetrahydrofuran; N,N-dimethyl-acetamide / 16 h / 45 °C
4.1: 100 percent / aq. HI / 1 h / 0 °C
5.1: iPrMgBr*LiCl / tetrahydrofuran / 0.25 h / -40 °C
5.2: ZnBr2 / tetrahydrofuran / -40 - 20 °C
5.3: 77 percent / Pd2(dba)3 / tetrahydrofuran / 16 h / 45 °C
6.1: 95 percent / aq. HI / 1 h / 0 °C
7.1: iPrMgBr*LiCl / tetrahydrofuran / 0.25 h / -40 °C
7.2: ZnBr2 / tetrahydrofuran / -40 - 20 °C
7.3: 46 percent / Pd2(dba)3 / tetrahydrofuran / 16 h / 45 °C
With
chloro-trimethyl-silane; tert.-butylnitrite; isopropylmagnesium chloride lithium chloride complex; N-benzyl-N,N,N-triethylammonium chloride; hydrogen iodide; ethylene dibromide; zinc;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
5.1: Negishi cross-coupling reaction / 7.1: Negishi cross-coupling reaction;
DOI:10.1002/ejoc.200600724
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 88 percent / aq. HI / 1 h / 0 °C
2.1: 1,2-dibromoethane; TMSCl; zinc / N,N-dimethyl-acetamide / 0.04 h / 20 °C
2.2: 61 percent / Pd2(dba)3; tfp / tetrahydrofuran; N,N-dimethyl-acetamide / 16 h / 45 °C
3.1: 100 percent / aq. HI / 1 h / 0 °C
4.1: iPrMgBr*LiCl / tetrahydrofuran / 0.25 h / -40 °C
4.2: ZnBr2 / tetrahydrofuran / -40 - 20 °C
4.3: 77 percent / Pd2(dba)3 / tetrahydrofuran / 16 h / 45 °C
5.1: 95 percent / aq. HI / 1 h / 0 °C
6.1: iPrMgBr*LiCl / tetrahydrofuran / 0.25 h / -40 °C
6.2: ZnBr2 / tetrahydrofuran / -40 - 20 °C
6.3: 46 percent / Pd2(dba)3 / tetrahydrofuran / 16 h / 45 °C
With
chloro-trimethyl-silane; isopropylmagnesium chloride lithium chloride complex; hydrogen iodide; ethylene dibromide; zinc;
In
tetrahydrofuran; N,N-dimethyl acetamide;
4.1: Negishi cross-coupling reaction / 6.1: Negishi cross-coupling reaction;
DOI:10.1002/ejoc.200600724
![9,9',9''-tribenzyl-6''-iodo-[6,8',6',8'']terpurine](/Databaselist/images/loading.webp)
