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N-(4-chlorophenyl)-3-fluoro-N'-hydroxy-2-naphthimidamide

Base Information
  • Chemical Name:N-(4-chlorophenyl)-3-fluoro-N'-hydroxy-2-naphthimidamide
  • CAS No.:1373121-92-6
  • Molecular Formula:C17H12ClFN2O
  • Molecular Weight:314.746
  • Hs Code.:
N-(4-chlorophenyl)-3-fluoro-N'-hydroxy-2-naphthimidamide

Synonyms:N-(4-chlorophenyl)-3-fluoro-N'-hydroxy-2-naphthimidamide

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Chemical Property of N-(4-chlorophenyl)-3-fluoro-N'-hydroxy-2-naphthimidamide
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Technology Process of N-(4-chlorophenyl)-3-fluoro-N'-hydroxy-2-naphthimidamide

There total 3 articles about N-(4-chlorophenyl)-3-fluoro-N'-hydroxy-2-naphthimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride / ethanol; water / 20 °C
2: N-chloro-succinimide / N,N-dimethyl-formamide / 0.25 h / 55 °C
3: tetrahydrofuran / 0 - 20 °C
With N-chloro-succinimide; hydroxylamine hydrochloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300043c
Guidance literature:
Multi-step reaction with 6 steps
1.1: sulfuric acid
2.1: tetrafluoroboric acid; sodium nitrite / water / 0.33 h / -15 - 0 °C
2.2: 3 h / Reflux
3.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C
4.1: hydroxylamine hydrochloride / ethanol; water / 20 °C
5.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.25 h / 55 °C
6.1: tetrahydrofuran / 0 - 20 °C
With N-chloro-succinimide; tetrafluoroboric acid; sulfuric acid; hydroxylamine hydrochloride; diisobutylaluminium hydride; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm300043c
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