1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Base Information

Chemical Name:1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid
CAS No.:1380587-34-7
Molecular Formula:C₂₈H₂₄N₂O₅
Molecular Weight:468.509
Hs Code.:

Synonyms:1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

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Chemical Property of 1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

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Technology Process of 1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

There total 12 articles about 1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.3%

: 1423694-17-0
C₂₉H₂₆N₂O₅

: 1380587-34-7
1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: C₂₉H₂₆N₂O₅; With water; lithium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In water;

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1380587-34-7
1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutylammomium bromide; potassium hydroxide / water; toluene / 65 °C

2.1: potassium hydroxide / ethylene glycol / 6 h / 160 °C

2.2: pH 3 - 4

3.1: sulfuric acid / 4 h / 65 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 80 °C / Inert atmosphere

6.1: lithium hydroxide; water / methanol / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; tetrabutylammomium bromide; water; sodium carbonate; potassium hydroxide; lithium hydroxide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; ethylene glycol; toluene;

Reference yield:

: 124276-67-1
1-(4-bromophenyl)cyclopropanecarbonitrile

: 1380587-34-7
1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethylene glycol / 6 h / 160 °C

1.2: pH 3 - 4

2.1: sulfuric acid / 4 h / 65 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 80 °C / Inert atmosphere

5.1: lithium hydroxide; water / methanol / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; water; sodium carbonate; potassium hydroxide; lithium hydroxide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; ethylene glycol;