ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate

Base Information

Chemical Name:ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate
CAS No.:1428797-01-6
Molecular Formula:C₂₂H₂₁FN₂O₄
Molecular Weight:396.418
Hs Code.:

Synonyms:ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate

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Chemical Property of ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate

Chemical Property:

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Technology Process of ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate

There total 11 articles about ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63375-81-5
2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine

: 1428797-01-6
ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 2 h / 120 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl acetamide / 20 - 140 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1428797-00-5
ethyl 1-(2-bromo-4,5-dimethoxyphenethyl)-5-(3-fluorophenyl)-1H-imidazole-4-carboxylate

: 1428797-01-6
ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl acetamide; at 20 - 140 ℃; Inert atmosphere;

Reference yield:

: 106469-78-7
tert-butyl (2-bromo-4,5-dimethoxyphenethyl)carbamate

: 1428797-01-6
ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / dichloromethane; ethyl acetate / 1 h / 20 °C

2: N,N-dimethyl-formamide / 2 h / 120 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl acetamide / 20 - 140 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;