(S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate
CAS No.:1514903-57-1
Molecular Formula:C₂₀H₂₉NO₅
Molecular Weight:363.454
Hs Code.:

Synonyms:(S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate

There total 3 articles about (S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1240530-29-3
(S)-tert-butyl 2-(2-(methoxy(methyl)amino)-2-oxoethyl)piperidine-1-carboxylate

: 89980-69-8
3,4-dimethoxyphenylmagnesium bromide

: 1514903-57-1
(S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol403229q

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 1514903-57-1
(S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: silver benzoate / 3 h / 0 - 20 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran / 4.5 h / -20 - -8 °C / Inert atmosphere

4.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With isopropylmagnesium chloride; silver benzoate; triethylamine; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1021/ol403229q

Reference yield:

: 199862-11-8
(S)-2-(diazoacetyl)piperidine-1-carboxylic acid tert-butyl ester

: 1514903-57-1
(S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: silver benzoate / 3 h / 0 - 20 °C / Inert atmosphere

2: isopropylmagnesium chloride / tetrahydrofuran / 4.5 h / -20 - -8 °C / Inert atmosphere

3: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With isopropylmagnesium chloride; silver benzoate; In tetrahydrofuran;
DOI:10.1021/ol403229q