(S)-(+)-3-HYDROXYBUTYRONITRILE

Base Information

• Chemical Name: (S)-(+)-3-HYDROXYBUTYRONITRILE
• CAS No.: 123689-95-2
• Molecular Formula: C4H7 N O
• Molecular Weight: 85.1057
• Hs Code.: 2926907090
• Mol file: 123689-95-2.mol

Synonyms:Butanenitrile,3-hydroxy-, (S)-

Chemical Property of (S)-(+)-3-HYDROXYBUTYRONITRILE

Chemical Property:

• Vapor Pressure: 0.029mmHg at 25°C
• Refractive Index: 1.426
• Boiling Point: 217.3 ºC at 760 mmHg
• Flash Point: 85.2 ºC
• PSA: 44.02000
• Density: 0.991 g/cm³
• LogP: 0.28088
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-3-Hydroxybutanenitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-(+)-3-HYDROXYBUTYRONITRILE

There total 12 articles about (S)-(+)-3-HYDROXYBUTYRONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-acetoxy-butyronitrile (54529-88-3) → 3-hydroxybutyronitrile (123689-95-2) + (R)-3-hydroxybutanonitrile (125103-95-9) + (S)-acetoxybutyronitrile (134527-00-7)

Guidance literature:

With 1,4,8,11-tetrathiacyclotetradecane; Lipase PS; In water; acetone; at 35 ℃; for 14h; Yields of byproduct given;

DOI:10.1021/jo971288m

Reference yield: 35.0%

(+/-)-3-<(methylthio)acetoxy>butyronitrile (125103-89-1) → 3-hydroxybutyronitrile (123689-95-2) + (R)-3-hydroxybutanonitrile (125103-95-9) + (S)-3-(methylthioacetoxy)butyronitrile (125136-88-1)

Guidance literature:

With phosphate buffer; In acetone; at 40 ℃; for 3h; Yield given. Yields of byproduct given; lipase P (Pseudomonas sp.);

DOI:10.1021/jo00004a033

Reference yield:

3-hydroxybutanenitrile (4368-06-3) → (S)-3-Hydroxybutanoic Acid (6168-83-8,26063-00-3,29435-48-1) + (R)-3-hydroxybutyric acid (625-72-9,26063-00-3,29435-48-1) + 3-hydroxybutyronitrile (123689-95-2) + (R)-3-hydroxybutanonitrile (125103-95-9)

Guidance literature:

With bacterial isolate; In aq. phosphate buffer; at 15 ℃; pH=7.2;

DOI:10.1016/j.molcatb.2013.08.001

upstream raw materials:

3-acetoxy-butyronitrile

(+/-)-3-(methoxyacetoxy)butyronitrile

(+/-)-3-<(butylthio)acetoxy>butyronitrile

(+/-)-3-(phenoxyacetoxy)butyronitrile