(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid

Base Information

• Chemical Name: (4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid
• CAS No.: 1425708-01-5
• Molecular Formula: C₂₃H₂₉NO₇S
• Molecular Weight: 463.552
• Mol file: 1425708-01-5.mol

Synonyms:(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid

Chemical Property of (4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid

There total 7 articles about (4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid methyl ester (1425707-99-8) → (4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid (1425708-01-5)

Guidance literature:

With Novozym 435; In aq. phosphate buffer; dichloromethane; acetone; at 50 ℃; for 23h; Inert atmosphere; Enzymatic reaction;

DOI:10.1002/chem.201202474

Reference yield:

benzeneacetic acid methyl ester (101-41-7) → (4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid (1425708-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1: chlorosulfonic acid / dichloromethane / 38 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

3: Novozym 435 / dichloromethane; aq. phosphate buffer; acetone / 23 h / 50 °C / Inert atmosphere; Enzymatic reaction

With chlorosulfonic acid; dmap; Novozym 435; triethylamine; In aq. phosphate buffer; dichloromethane; acetone;

DOI:10.1002/chem.201202474

Reference yield:

2-(4-(chlorosulfonyl)phenyl)acetic acid methyl ester (53305-12-7) → (4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid (1425708-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: Novozym 435 / dichloromethane; aq. phosphate buffer; acetone / 23 h / 50 °C / Inert atmosphere; Enzymatic reaction

With dmap; Novozym 435; triethylamine; In aq. phosphate buffer; dichloromethane; acetone;

DOI:10.1002/chem.201202474

upstream raw materials:

benzeneacetic acid methyl ester

2-(4-(chlorosulfonyl)phenyl)acetic acid methyl ester

(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)acetic acid methyl ester

4-(phenylamino)butan-1-ol