(R)-(+)-2-Amino-3-methyl-1,1-diphenyl-1-butanol

Base Information

• Chemical Name: (R)-(+)-2-Amino-3-methyl-1,1-diphenyl-1-butanol
• CAS No.: 86695-06-9
• Molecular Formula: C17H21NO
• Molecular Weight: 255.36
• Hs Code.: 29062990
• European Community (EC) Number: 623-411-2
• Mol file: 86695-06-9.mol

Synonyms:(R)-(+)-2-Amino-3-methyl-1,1-diphenyl-1-butanol;86695-06-9;(2r)-2-amino-3-methyl-1,1-diphenylbutan-1-ol;R-2-AMINO-3-METHYL-1,1-DIPHENYLBUTAN-1-OL;(r)-2-amino-3-methyl-1,1-diphenylbutan-1-ol;Oprea1_417947;SCHEMBL1131649;CCG-55507;FD1205;AKOS015853835;CS-W012575;DS-1784;AC-23804;AM20060741;(2R)-2-Amino-3-methyl-1,1-diphenyl-1-butanol;(R)- 2-Amino-3-methyl-1,1-diphenyl-1-butanol;A863081;SR-01000644529-1;(R)-(+)-2-Amino-3-methyl-1,1-diphenyl-1-butanol, 95%

Chemical Property of (R)-(+)-2-Amino-3-methyl-1,1-diphenyl-1-butanol

Chemical Property:

• Vapor Pressure: 5.73E-08mmHg at 25°C
• Melting Point: 95-99 °C(lit.)
• Refractive Index: 1.576
• Boiling Point: 424.7 °C at 760 mmHg
• PKA: 11.20±0.50(Predicted)
• Flash Point: 210.6 °C
• PSA: 46.25000
• Density: 1.074 g/cm³
• LogP: 3.60610
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 255.162314293
• Heavy Atom Count: 19
• Complexity: 246

Purity/Quality:

99% ^*data from raw suppliers

(R)-(+)-2-Amino-3-methyl-1,1-diphenyl-1-butanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(C1=CC=CC=C1)(C2=CC=CC=C2)O)N
• Isomeric SMILES: CC(C)[C@H](C(C1=CC=CC=C1)(C2=CC=CC=C2)O)N

Technology Process of (R)-(+)-2-Amino-3-methyl-1,1-diphenyl-1-butanol

There total 8 articles about (R)-(+)-2-Amino-3-methyl-1,1-diphenyl-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-1-tert-butyl-N-(1-(methoxymethoxy)-3-methyl-1,1-diphenylbutan-2-yl)-1-(λ1-oxidanyl)-λ3-sulfanamine → (R)-(+)-2-amino-3-methyl-1,1-diphenylbutan-1-ol (86695-06-9)

Guidance literature:

(R)-1-tert-butyl-N-(1-(methoxymethoxy)-3-methyl-1,1-diphenylbutan-2-yl)-1-(λ¹-oxidanyl)-λ³-sulfanamine; With hydrogenchloride; In methanol; at 0 - 70 ℃; for 4h;

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 20 ℃; for 6h;

DOI:10.1021/acs.joc.8b01381

Reference yield: 52.0%

D-Valine methyl ester hydrochloride (7146-15-8) + phenylmagnesium bromide → (R)-(+)-2-amino-3-methyl-1,1-diphenylbutan-1-ol (86695-06-9)

Guidance literature:

In tetrahydrofuran; at 0 - 10 ℃; for 5h;

DOI:10.1039/P19850002039

Reference yield: 26.0%

(2R)-N-Boc-2-amino-1,1-diphenyl-3-methylbutanol (223906-36-3) → (R)-(+)-2-amino-3-methyl-1,1-diphenylbutan-1-ol (86695-06-9)

Guidance literature:

With hydrogenchloride; methanol; at 20 ℃;

DOI:10.1021/jo020442o

upstream raw materials:

D-Val-OH

D-Valine methyl ester hydrochloride

(2R)-N-Boc-2-amino-1,1-diphenyl-3-methylbutanol

(R)-methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate