BOC-D-VALINE METHYL ESTER

Base Information

• Chemical Name: BOC-D-VALINE METHYL ESTER
• CAS No.: 106391-85-9
• Molecular Formula: C11H21 N O4
• Molecular Weight: 231.292
• Hs Code.: 2924199090
• Mol file: 106391-85-9.mol

Synonyms:N-tert-Butoxycarbonyl-D-valinemethyl ester

Chemical Property of BOC-D-VALINE METHYL ESTER

Chemical Property:

• Boiling Point: 306.0±25.0 °C(Predicted)
• PKA: 11.13±0.46(Predicted)
• PSA: 64.63000
• Density: 1.020±0.06 g/cm3(Predicted)
• LogP: 2.09960

Purity/Quality:

98%min ^*data from raw suppliers

D-BocValineMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-VALINE METHYL ESTER

There total 33 articles about BOC-D-VALINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + N-(Benzyloxycarbonyl)valine methyl ester (134306-34-6) → N-Boc-valine methyl ester (58561-04-9,106391-85-9,145618-65-1)

Guidance literature:

With triethylsilane; palladium diacetate; triethylamine; In ethanol; for 15h; Ambient temperature;

DOI:10.1016/0040-4039(88)85064-0

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-methyl 2-amino-3-methylbutanoate hydrochloride → (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate (106391-85-9)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 0 - 20 ℃;

Reference yield: 87.0%

di-tert-butyl dicarbonate (24424-99-5) + D-Valine methyl ester hydrochloride (7146-15-8) → (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate (106391-85-9)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 20h; Inert atmosphere;

DOI:10.1039/c7ob00913e

upstream raw materials:

di-tert-butyl dicarbonate

N-(Benzyloxycarbonyl)valine methyl ester

methanol

N-Boc-(S/R)-valine

Downstream raw materials:

(2R)-N-Boc-2-amino-1,1-diphenyl-3-methylbutanol

D-Valine methyl ester hydrochloride

(R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methylene)amino]-2,4-dimethylpentan-2-ol

(3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol

Refernces

• 1、 Burkhardt, Immo,Lauterbach, Lukas,Brock, Nelson L.,Dickschat, Jeroen S.. "Chemical differentiation of three DMSP lyases from the marine: Roseobacter group". . p. 4432 - 4439. Retrieved 2017.
• 2、 Sakaitani, Masahiro,Hori, Keiko,Ohfune, Yasufumi. "ONE-POT CONVERSION OF N-BENZYLOXYCARBONYL GROUP INTO N-TERT-BUTOXYCARBONYL GROUP". . p. 2983 - 2984. Retrieved 1988.
• 3、 An, Zhengfang,Gu, Xiaoxu,Liu, Yue,Ge, Jingyan,Zhu, Qing. "Bioproduction of l-2-Aminobutyric Acid by a Newly-Isolated Strain of Aspergillus tamarii ZJUT ZQ013". . p. 837 - 844. Retrieved 2017/03/24.