methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate

Base Information

• Chemical Name: methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate
• CAS No.: 53510-38-6
• Molecular Formula: C₂₉H₃₇NO₇
• Molecular Weight: 511.615
• Mol file: 53510-38-6.mol

Synonyms:methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate

Chemical Property of methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate

There total 29 articles about methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

acetic anhydride (108-24-7) + trans-quinolizidinol (51491-58-8,51491-59-9,87201-62-5) → 3-{4-[2-((2R,4S,9aS)-2-Acetoxy-octahydro-quinolizin-4-yl)-4,5-dimethoxy-phenoxy]-phenyl}-propionic acid methyl ester (50412-58-3,53510-38-6,97387-81-0)

Guidance literature:

In pyridine; for 15h; Ambient temperature;

DOI:10.1248/cpb.33.532

Reference yield: 83.6%

acetic anhydride (108-24-7) + cis-quinolizidinol (51491-58-8,51491-59-9,87201-62-5) → methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate (53510-38-6)

Guidance literature:

With pyridine; Ambient temperature;

DOI:10.1016/S0040-4039(00)88022-3

Reference yield:

3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2) → methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate (53510-38-6)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃, CuO / pyridine / 5 h / 120 - 150 °C

2: 99 percent / HgO / CH₂Cl₂ / 1.5 h / Heating

3: 1) methanesulfonyl chloride 2) Zn / 1) CH₂Cl₂, 0 deg C, 1.2 h; 2) aq. AcOH, room temp., 2.5 h

4: 83.2 percent / pyridine / 4 h / Ambient temperature

With potassium carbonate; methanesulfonyl chloride; copper(II) oxide; mercury(II) oxide; zinc; In pyridine; dichloromethane;

DOI:10.1248/cpb.33.532

upstream raw materials:

3-(4-hydroxyphenyl)propionic acid methyl ester

rel-(2R,4S,10R)-2-acetoxy-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizine

rel-(2R,4S,10R)-2-acetoxy-4-(3,4-dimethoxy-6-iodophenyl)octahydro-4H-quinolizine

acetic anhydride

Downstream raw materials:

3-{4-[2-((2S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-4,5-dimethoxy-phenoxy]-phenyl}-propionic acid

3-{4-[2-((2R,4S,9aS)-2-Hydroxy-octahydro-quinolizin-4-yl)-4,5-dimethoxy-phenoxy]-phenyl}-propionic acid