2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid

Base Information

Chemical Name:2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid
CAS No.:1168131-65-4
Molecular Formula:C₂₂H₂₃ClN₂O₄
Molecular Weight:414.889
Hs Code.:

Synonyms:2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid

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Chemical Property of 2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid

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Technology Process of 2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid

There total 10 articles about 2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1168133-93-4
2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

: 1168131-65-4
2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid

Guidance literature:: 2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester; With ethanol; water; potassium hydroxide; for 2h; Reflux;

With hydrogenchloride; water; pH=5;

Reference yield:

: 1168133-92-3
2-(3-chloro-5-cyclopropylmethoxy-4-iodophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

: 1168131-65-4
2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 18 h / 100 °C / Inert atmosphere

2: water; potassium hydroxide / ethanol / 2 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; cesium fluoride; potassium hydroxide; In 1,2-dimethoxyethane; ethanol;

Reference yield:

: 1168133-91-2
2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

: 1168131-65-4
2-(4-benzo[c][1,2,5]oxadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; sulfuric acid / water; ethanol / 0.5 h / 0 °C

1.2: 2.5 h / 0 - 60 °C

2.1: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 18 h / 100 °C / Inert atmosphere

3.1: water; potassium hydroxide / ethanol / 2 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; water; cesium fluoride; potassium hydroxide; sodium nitrite; In 1,2-dimethoxyethane; ethanol; water;