2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Base Information

Chemical Name:2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester
CAS No.:1168133-91-2
Molecular Formula:C₂₀H₂₈ClNO₃
Molecular Weight:365.9
Hs Code.:

Synonyms:2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

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Chemical Property of 2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Chemical Property:

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Technology Process of 2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

There total 7 articles about 2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1168133-90-1
2-(4-amino-3-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

: 1168133-91-2
2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Guidance literature:: 2-(4-amino-3-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester; With N-chloro-succinimide; In chloroform; for 1h; Reflux;

With water; potassium carbonate; In chloroform;

Reference yield:

: 10203-58-4
(2-methylpropyl)-propanedioic acid, diethyl ester

: 1168133-91-2
2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.83 h / 0 °C

1.2: 16 h / 0 - 25 °C

2.1: sulfuric acid / acetic acid; water / 24 h / Reflux

3.1: sulfuric acid / 3 h / Reflux

4.1: n-butyllithium / hexane / 1 h / -15 - 25 °C

4.2: 16 h / 25 °C

5.1: zinc / acetic acid; water / 1 h / Reflux

6.1: N-chloro-succinimide / chloroform / 1 h / Reflux

With N-chloro-succinimide; n-butyllithium; sulfuric acid; sodium hydride; zinc; In hexane; chloroform; water; acetic acid; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1168133-86-5
2-(3-fluoro-4-nitrophenyl)-2-isobutylmalonic acid diethyl ester

: 1168133-91-2
2-(4-amino-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / acetic acid; water / 24 h / Reflux

2.1: sulfuric acid / 3 h / Reflux

3.1: n-butyllithium / hexane / 1 h / -15 - 25 °C

3.2: 16 h / 25 °C

4.1: zinc / acetic acid; water / 1 h / Reflux

5.1: N-chloro-succinimide / chloroform / 1 h / Reflux

With N-chloro-succinimide; n-butyllithium; sulfuric acid; zinc; In hexane; chloroform; water; acetic acid;