N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide

Base Information

• Chemical Name: N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide
• CAS No.: 229008-29-1
• Molecular Formula: C₂₆H₂₅NO₂
• Molecular Weight: 383.49
• Mol file: 229008-29-1.mol

Synonyms:N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide

Chemical Property of N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide

There total 24 articles about N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-aminobenzenemethanol (623-04-1) + 2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid (229006-88-6) → N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide (229008-29-1)

Guidance literature:

2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 30 ℃; for 1h; Large scale;

4-aminobenzenemethanol; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Large scale;

DOI:10.1021/op000074v

Reference yield: 56.0%

4-aminobenzyl O-2'-tetrahydropyranyl ether (18484-05-4) + triethylamine (Et3 N) + 2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid (229006-88-6) → N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide (229008-29-1)

Guidance literature:

With hydrogenchloride; (COCl)2; In tetrahydrofuran; methanol (MeOH); water; N,N-dimethyl-formamide;

Reference yield: 52.0%

3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-amide → N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide (229008-29-1)

Guidance literature:

With hydrogenchloride; In acetone; at 20 ℃; for 0.75h;

DOI:10.1021/jm9906264

upstream raw materials:

ethyl glutaroyl chloride

bromobenzene

4-nitrobenzyl chloride

4-bromo-δ-oxobenzenepentanoic acid

Downstream raw materials:

TAK-779

N-(4-chloromethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide