(1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate

Base Information

Chemical Name:(1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate
CAS No.:1026863-90-0
Molecular Formula:C₂₁H₂₂F₂O₂S
Molecular Weight:376.467
Hs Code.:

Synonyms:(1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate

Suppliers and Price of (1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate

There total 6 articles about (1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 65-85-0,8013-63-6
benzoic acid

: 156483-97-5
(1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexanol

: 1026863-90-0
(1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jo00091a041

Reference yield:

: 1517-82-4
(-)-menthyl p-toluenesulfinate

: 1026863-90-0
(1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LDA / tetrahydrofuran / 0.08 h / -65 °C

2: 14.6 percent / sodium borohydride, 30percent aq. ammonia / methanol / 0.17 h / 20 °C

3: 96 percent / trifluoroacetic anhydride, NaI / acetone / 0.17 h / -40 °C

4: 60 percent / AIBN, tributyltin hydride / benzene / 70 °C

5: 79 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; ammonium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; acetone; benzene;
DOI:10.1021/jo00091a041

Reference yield:

: 156558-20-2
(2R,3R,R_S)-1-chloro-1,1-difluoro-3-<(4-methylphenyl)sulphinyl>hept-6-en-2-ol

: 1026863-90-0
(1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / trifluoroacetic anhydride, NaI / acetone / 0.17 h / -40 °C

2: 60 percent / AIBN, tributyltin hydride / benzene / 70 °C

3: 79 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; sodium iodide; In dichloromethane; acetone; benzene;
DOI:10.1021/jo00091a041