Technology Process of (1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate
There total 6 articles about (1S,3R,6R)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)thio>cyclohexyl benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; dicyclohexyl-carbodiimide;
In
dichloromethane;
for 1h;
Ambient temperature;
DOI:10.1021/jo00091a041
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / LDA / tetrahydrofuran / 0.08 h / -65 °C
2: 14.6 percent / sodium borohydride, 30percent aq. ammonia / methanol / 0.17 h / 20 °C
3: 96 percent / trifluoroacetic anhydride, NaI / acetone / 0.17 h / -40 °C
4: 60 percent / AIBN, tributyltin hydride / benzene / 70 °C
5: 79 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH2Cl2 / 1 h / Ambient temperature
With
dmap; ammonium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; sodium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; acetone; benzene;
DOI:10.1021/jo00091a041
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / trifluoroacetic anhydride, NaI / acetone / 0.17 h / -40 °C
2: 60 percent / AIBN, tributyltin hydride / benzene / 70 °C
3: 79 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH2Cl2 / 1 h / Ambient temperature
With
dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; sodium iodide;
In
dichloromethane; acetone; benzene;
DOI:10.1021/jo00091a041
