N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide
CAS No.:864875-31-0
Molecular Formula:C₂₁H₂₇NO₄S
Molecular Weight:389.516
Hs Code.:

Synonyms:N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

Suppliers and Price of N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

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Chemical Property of N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

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Technology Process of N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

There total 5 articles about N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 851487-22-4
N-[(E)-(4S,5R)-4-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-hydroxy-7-phenyl-hept-2-enyl]-4-methyl-benzenesulfonamide

: 864875-31-0
N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; ethanol; at 0 ℃; for 2h;
DOI:10.1246/bcsj.78.1309

Reference yield:

: (2'R,2E)-3-(1'-tosylaziridin-2'-yl)acrylic methyl ester

: 864875-31-0
N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiOH / dioxane; methanol; H₂O / 4 h / 20 °C

2.1: pivaloyl chloride; Et₃N / tetrahydrofuran / 0.75 h / 0 °C

2.2: 47 percent / LiCl / tetrahydrofuran / 0 - 20 °C

3.1: 93 percent / SmI₂ / tetrahydrofuran / 0.5 h / -78 °C

4.1: 75 percent / LiBH₄ / ethanol; tetrahydrofuran / 2 h / 0 °C

With lithium hydroxide; lithium borohydride; samarium diiodide; pivaloyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;
DOI:10.1246/bcsj.78.1309

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 864875-31-0
N-((E)-(4R,5R)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: SmI₂ / tetrahydrofuran / 1 h / -78 °C

2: 68 percent / DIBAL / CH₂Cl₂ / 2 h / -20 °C

With samarium diiodide; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1246/bcsj.78.1309