3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one

Base Information

Chemical Name:3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one
CAS No.:1610926-29-8
Molecular Formula:C₂₅H₃₁NO₃
Molecular Weight:393.526
Hs Code.:

Synonyms:3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one

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Chemical Property of 3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one

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Technology Process of 3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one

There total 4 articles about 3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 15357-92-3
6-methoxy-7-(benzyloxy)-3,4-dihydroisoquinoline

: 91342-74-4
3-[(dimethylamino)methyl]-5-methylhexan-2-one

: 1610926-29-8
3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; In water; at 90 ℃; for 4h;
DOI:10.1002/ardp.201300307

Reference yield:

: 21473-46-1
2-(4'-benzyloxy-3'-methoxyphenyl)-1-nitroethane

: 1610926-29-8
3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; hexamethylenetetramine / 2.5 h / 20 - 80 °C

2: N-benzyl-N,N,N-triethylammonium chloride / water / 4 h / 90 °C

With hexamethylenetetramine; N-benzyl-N,N,N-triethylammonium chloride; acetic acid; In water; 1: |Bischler-Napieralski Reaction / 2: |Michael Addition;
DOI:10.1002/ardp.201300307

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1610926-29-8
3-isobutyl-9-methoxy-10-benzyloxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate; acetic acid / 2 h / 40 - 130 °C

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3 h / 0 - 60 °C

3: acetic acid; hexamethylenetetramine / 2.5 h / 20 - 80 °C

4: N-benzyl-N,N,N-triethylammonium chloride / water / 4 h / 90 °C

With lithium aluminium tetrahydride; hexamethylenetetramine; ammonium acetate; N-benzyl-N,N,N-triethylammonium chloride; acetic acid; In tetrahydrofuran; diethyl ether; water; 1: |Knoevenagel Condensation / 3: |Bischler-Napieralski Reaction / 4: |Michael Addition;
DOI:10.1002/ardp.201300307