15357-92-3Relevant articles and documents
A Modular Access to (±)-Tubocurine and (±)-Curine - Formal Total Synthesis of Tubocurarine
Otto, Nicola,Ferenc, Dorota,Opatz, Till
, p. 1205 - 1217 (2018/06/18)
Two consecutive Cu-catalyzed Ullmann-type C-O couplings permitted the first successful entry toward the curare alkaloids (±)-tubocurine and (±)-curine. Starting from vanillin, the synthetic sequence comprises 15 linear steps and includes a total of 24 transformations. In addition, the total synthesis of tubocurine represents a formal total synthesis of the famous arrow poison alkaloid tubocurarine.
Synthesis and biological evaluation of 10-11C- dihydrotetrabenazine as a vesicular monoamine transporter 2 radioligand
Li, Xiaomin,Chen, Zhengping,Tang, Jie,Liu, Chunyi,Zou, Pei,Huang, Hongbo,Tan, Cheng,Yu, Huixin
, p. 313 - 319 (2014/05/20)
In this study, we synthesized a new carbon-11-labeled radiotracer, 10- 11C-dihydrotetrabenazine (10-11C-DTBZ), and evaluated its potential as a vesicular monoamine transporter 2 (VMAT2) radioligand. The radiolabeled precursor 10-O-de
Formal synthesis of the bisbenzylisoquinoline alkaloid berbamunine by asymmetric substitution of chiral organolithium compounds
Gawley, Robert E.,Smith, Gregory A.
, p. 167 - 179 (2011/07/07)
Asymmetric alkylation of enantiomeric tetrahydroisoquinolyl oxazolines was achieved with 96-97% diastereoselectivity. Removal of the oxazoline chiral auxiliary and further transformations provide a straightforward synthesis of the two synthetic intermediates that were previously synthesized by resolution, and which comprise a formal synthesis of berbamunine by Ullman coupling. ARKAT-USA, Inc.