4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Base Information

Chemical Name:4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide
CAS No.:837408-79-4
Molecular Formula:C₃₈H₅₄N₄O₅SSi
Molecular Weight:707.022
Hs Code.:

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Synonyms:4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

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Chemical Property of 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

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Technology Process of 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

There total 7 articles about 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138402-05-8
2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one

: 837408-69-2
N-(3,4-dimethyl-5-isoxazolyl)-4'-bromomethyl-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

: 837408-79-4
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-(3,4-dimethyl-5-isoxazolyl)-4'-bromomethyl-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm049548x

Reference yield:

: 89003-95-2
3-formaldehyde-4-bromobenzonitrile

: 837408-79-4
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran; diethyl ether; hexane / 3 h / 20 °C

1.2: tetrahydrofuran; diethyl ether; hexane / 16 h / 20 °C

2.1: PtO₂; H₂ / ethanol / 0.67 h / 1810.02 Torr

3.1: 1.3 g / DIBAL-H / toluene / 2 h / 20 °C

4.1: 52 percent / Pd(PPh₃)4; aq. Na₂CO₃ / aq. ethanol; toluene / 2.5 h / 85 °C

5.1: NaBH₄ / methanol / 2 h / 20 °C

6.1: 1.2 g / CBr₄; PPh₃ / dimethylformamide / 2 h / 0 °C

7.1: NaH / dimethylformamide / 0.5 h / 20 °C

7.2: 1.2 g / dimethylformamide / 3 h / 20 °C

With platinum(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; carbon tetrabromide; hydrogen; sodium hydride; diisobutylaluminium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene; 1.2: Witting olefination / 4.1: Suzuki coupling;
DOI:10.1021/jm049548x

Reference yield:

: 254745-39-6
4-bromo-3-propylbenzaldehyde

: 837408-79-4
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 52 percent / Pd(PPh₃)4; aq. Na₂CO₃ / aq. ethanol; toluene / 2.5 h / 85 °C

2.1: NaBH₄ / methanol / 2 h / 20 °C

3.1: 1.2 g / CBr₄; PPh₃ / dimethylformamide / 2 h / 0 °C

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: 1.2 g / dimethylformamide / 3 h / 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; In methanol; ethanol; N,N-dimethyl-formamide; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm049548x