89003-95-2

Usage

Uses

Used in Organic Synthesis:
4-Bromo-3-Formyl-Benzonitrile is used as a synthetic intermediate for the preparation of more complex molecules. Its bromine atom provides halogen bonding capabilities, which can be exploited in the synthesis of halogenated compounds and other derivatives.
Used in Pharmaceutical Industry:
4-Bromo-3-Formyl-Benzonitrile is used as a building block in the development of new pharmaceutical compounds. The presence of the aldehyde and nitrile groups allows for further chemical modifications, potentially leading to the creation of novel drug candidates with improved therapeutic properties.
Used in Material Science:
4-Bromo-3-Formyl-Benzonitrile is used as a precursor in the synthesis of advanced materials, such as polymers and composites. The versatility of its chemical groups enables the creation of materials with tailored properties for specific applications, such as electronics, coatings, or adhesives.
Used in Chemical Research:
4-Bromo-3-Formyl-Benzonitrile is used as a model compound in academic research to study the reactivity and properties of different functional groups. Its unique combination of a bromide, aldehyde, and nitrile groups makes it an interesting subject for exploring new reaction pathways and understanding the fundamental principles of organic chemistry.

InChI:InChI=1/C8H4BrNO/c9-8-2-1-6(4-10)3-7(8)5-11/h1-3,5H

Upstream product

• 89003-94-1 Acetic acid acetoxy-(2-bromo-5-cyano-phenyl)-methyl ester 
• 160313-49-5 3-(dibromomethyl)-4-bromobenzonitrile 

Downstream Products

• 254745-31-8 4-bromo-3-(1-propen-1-yl)benzonitrile 
• 254745-39-6 4-bromo-3-propylbenzaldehyde 
• 254745-36-3 4-bromo-3-propylbenzonitrile 
• 1026906-58-0 4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide 
• 837408-79-4 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide 
• 1219831-94-3 3-Formyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile 
• 160313-50-8 2-[(2'-bromo-5'-cyano)phenyl]-1,3-dioxolane 
• 89003-96-3 4-Bromo-3-((E)-3-oxo-3-phenyl-propenyl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Indole compound as well as preparation method, pharmaceutical composition and application thereof

The invention discloses an indole compound as well as a preparation method, a pharmaceutical composition and an application thereof. Specifically, the invention relates to an indole derivative as shown in a general formula I and a medicinal salt thereof, a preparation method of the indole derivative, a composition containing one or more compounds, and applications of the compounds in preparation of medicines for preventing and/or treating diseases related to IDO1 and/or TDO.

1-HYDROXY-1,3-DIHYDROBENZO[c][1,2]OXABOROLES AND THEIR USE AS HERBICIDES

Provided herein are 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaboroles and their derivatives, and compositions and methods of use thereof as herbicides.

N-acyl sulfamide FBPase inhibitor, preparation method thereof, drug composition and application

The invention discloses an N-acryl sulfamide FBPase inhibitor of a novel structure, and a preparation method thereof, a drug composition and an application, and particularly relates to an N-acryl sulfamide FBPase inhibitor shown in the formula I, a salt thereof for medicine, a preparation method, a composition comprising one or more compounds, an application of the compound in preparing the FBPase inhibitor or a drug for treating FBPase-related diseases, and an application in preparing a drug for preventing and/or treating diabetes. The formula is shown in the description.

HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS

Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

Fluorescence sensing based on cation-induced conformational switching: Copper-selective modulation of the photoinduced intramolecular charge transfer of a donor-acceptor biphenyl fluorophore

The fluorescence emission energy of donor-acceptor substituted biphenyls is highly sensitive towards conformational changes of the interannular twist angle. By integrating 4-dimethylamino-4′-cyano-biphenyl into the ligand backbone of a thioether-rich metal receptor we designed a fluorescence sensor that exhibits high selectivity towards copper. Upon metal binding the ligand undergoes a significant conformational change, which induces a strong hypsochromic shift of the photoinduced charge-transfer emission. Steady-state absorption and fluorescence spectroscopy revealed a high affinity towards Cu(I) with a well-defined 1:1 metal-ligand complex stoichiometry. The nature of the conformational changes upon Cu(I) coordination were analyzed in detail by 1H NMR and 2D NOESY experiments. The spectroscopic data provide a coherent picture, which is consistent with a Boltzmann ground-state distribution of several rotamers that are locked into a more flattened geometry upon coordination of Cu(I).

Photocyclization of Aryl Halides. Part 4. 5-(2-Halogenophenyl)-1,3-diphenyl-Δ2-pyrazolines. Predissociation and Electron Transfer between Intramolecular but Separate Chromophores

Photoreaction of 5-(2-iodophenyl)-1,3-diphenyl-Δ2-pyrazoline proceeds by simple bond homolysis from the S1deg state to give 1,3,5-triphenylpyrazoline and 2-phenylpyrazolophenanthridine in a ratio which depends on the hydrogen atom donor ability of the hydrocarbon solvent.The quantum yield for decomposition of the iodo-compound depends on the viscosity of the hydrocarbon solvent and on the temperature.The corresponding chloro- and bromo-compounds as well as the 3-iodo- and 4-iodo-phenyl compounds are photostable.Consideration of these facts and the complementary fluorescence data suggest a mechanism of interchromophoric predissociation to an n?* state.However, examples are given where there is a smaller electron donor-acceptor energy gap between the two chromophores so that photoreaction occurs by an electron transfer pathway.