tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Base Information

Chemical Name:tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate
CAS No.:174774-25-5
Molecular Formula:C₂₇H₃₈N₄O₆
Molecular Weight:514.622
Hs Code.:

Synonyms:tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

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Chemical Property of tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

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Technology Process of tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

There total 6 articles about tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 174775-08-7
[(4-{[5-(benzyloxycarbonylamino-imino-methyl)-benzofuran-2-carbonyl]-amino}-cyclohexyl)-tert-butoxycarbonyl-amino]-acetic acid tert-butyl ester

: 174774-25-5
tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 16h; Heating;
DOI:10.1248/cpb.47.1694

Reference yield:

: 84102-75-0
5-cyanobenzo[b]furan-2-carboxylic acid

: 174774-25-5
tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: HCl

2: NH₃ / ethanol

3: aq. NaOH / tetrahydrofuran

4: 37 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

5: 86 percent / H₂ / 10 percent Pd/C / ethanol / 16 h / Heating

With hydrogenchloride; sodium hydroxide; ammonia; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: Pinner reaction / 2: aminolysis / 3: Acylation / 4: coupling / 5: Hydrogenolysis;
DOI:10.1248/cpb.47.1694

Reference yield:

: 174774-65-3
5-(benzyloxycarbonylamidino)-2-benzofurancarboxylic acid

: 174774-25-5
tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

2: 86 percent / H₂ / 10 percent Pd/C / ethanol / 16 h / Heating

With hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 1: coupling / 2: Hydrogenolysis;
DOI:10.1248/cpb.47.1694