84102-75-0

Usage

Uses

Used in Pharmaceutical Industry:
5-Cyano-2-benzo[b]furancarboxylic acid is used as a building block for the synthesis of various pharmaceuticals. Its cyano and carboxylic acid functional groups allow for the creation of diverse organic compounds, making it a valuable intermediate in drug development. 5-Cyano-2-benzo[b]furancarboxylic acid's potential biological activity also makes it a promising candidate for the development of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Cyano-2-benzo[b]furancarboxylic acid serves as a key intermediate in the synthesis of various agrochemicals. Its functional groups enable the production of a wide range of compounds with potential applications in crop protection and pest control. 5-Cyano-2-benzo[b]furancarboxylic acid's versatility and potential biological activity contribute to its importance in the development of innovative and effective agrochemical products.

Upstream product

• 80531-14-2 2-Acetyl-1-benzofuran-5-carbonitril 
• 10242-11-2 5-bromobenzo[b]furan-2-carboxylic acid 
• 24581-99-5 methyl (4-bromo-2-formylphenoxy)acetate 
• 26028-36-4 5-bromo-2-benzofurancarboxylic acid methyl ester 
• 84102-77-2 methyl 5-cyanobenzofuran-2-carboxylate 
• 38220-75-6 2-acetyl-5-bromobenzo[b]furan 
• 1761-61-1 5-bromosalicyclaldehyde 

Downstream Products

• 84102-83-0 5-Cyan-1-benzofuran-2-carbonylchlorid 
• 84102-97-6 5-Cyan-N-(4-cyanphenyl)-1-benzofuran-2-carboxamid 
• 174774-61-9 methyl 3-[4-(5-cyanobenzofuran-2-carboxamido)phenyl]propionate 
• 221161-00-8 4-{4-[(5-cyano-benzofuran-2-carbonyl)-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester 
• 174774-94-8 5-benzylamidino-2-benzofurancarboxylic acid 
• 174774-95-9 ethyl 5-benzylamidino-2-benzofurancarboxylate hydrochloride 
• 1299483-16-1 5-(aminomethyl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2-carboxamide 
• 1299482-48-6 5-(Acetamidomethyl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2-carboxamide 
• 1299482-39-5 5-cyano-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2-carboxamide 
• 84102-99-8 4',5-Bis(2-imidazolin-2-yl)-1-benzofuran-2-carboxanilid-dihydrochlorid 
• 84102-98-7 5-Amidino-N-(4-amidinophenyl)-1-benzofuran-2-carboxamid-dihydrochlorid 
• 174774-32-4 di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate 
• 174775-08-7 [(4-{[5-(benzyloxycarbonylamino-imino-methyl)-benzofuran-2-carbonyl]-amino}-cyclohexyl)-tert-butoxycarbonyl-amino]-acetic acid tert-butyl ester 
• 174775-39-4 [(4-{[5-(benzyloxycarbonylamino-imino-methyl)-benzofuran-2-carbonyl]-amino}-cyclohexyl)-butyl-amino]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

BITTER TASTE MODULATORS

The present invention includes antagonists of human type 2 taste receptors (hT2Rs) having structural Formula (I). The present invention also provides compositions containing these antagonists, the use of these antagonists for modulating taste perception, particularly bitter taste, and the method of preparing these antagonists (I).

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists

The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa) antagonists is described. The additional conformational restriction offered by the bicyclic nucleus results in 20-400-fold increases in potency compared to the freely flexible, acyclic benzamidine counterpart. The design, synthesis, structure-activity relationships (SAR), and in vitro activity of this novel class of GPIIb-IIIa antagonists are presented.

5,6-Bicyclic glycoprotein IIb IIIa antagonists useful in inhibition of platelet aggregation

This invention relates to 5,6 fused ring bicyclic compounds inclusive of indoles, benzofurans, and benzothiophenes, and corresponding to the formula (I) substituted with both basic (B) and acidic (A) functionality, which are useful in inhibition of platelet aggregation.

Syntheses of Biscationic, Trypanocidal 1-Benzofuran Compounds

2-Phenyl-1-benzofurans with the substituents Br, NO2, CN, and -NH2, -NH-C(=NH)-NH2, -C(=NH)-NH2, in 4',5-position were synthesized. - For arylated formamidine derivatives a simple new preparation was found by reacting amine hydrochlorides with dimethylformamide in the presence of cyanamide. - Based on 5- or 6-cyano-1-benzofuran-2-carboxylates a series of α,ω-bis(1-benzofuran-2-yl) derivatives with cyano-, amidino-, or imidazolinyl groups in 5- or 6-position was prepared.