C₁₄H₁₁BrN₂O

Base Information

Chemical Name:C₁₄H₁₁BrN₂O
CAS No.:1402652-62-3
Molecular Formula:C₁₄H₁₁BrN₂O
Molecular Weight:303.158
Hs Code.:

C<sub>14</sub>H<sub>11</sub>BrN<sub>2</sub>O

Synonyms:C₁₄H₁₁BrN₂O

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Chemical Property of C₁₄H₁₁BrN₂O

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Technology Process of C₁₄H₁₁BrN₂O

There total 8 articles about C₁₄H₁₁BrN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402652-61-2
6-bromo-7-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile

: 1402652-62-3
C₁₄H₁₁BrN₂O

Guidance literature:: 6-bromo-7-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

With methanol; In dichloromethane; at 0 ℃;

Reference yield:

: 4513-94-4
1H-pyrrole-2-carbonitrile

: 1402652-62-3
C₁₄H₁₁BrN₂O

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine; acetic acid / 23.5 h

2.1: potassium carbonate / acetonitrile / 0.5 h / 80 °C / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave

4.1: 1,2-dimethoxyethane; water / 0.5 h / 120 °C

5.1: Hoveyda-Grubbs catalyst / dichloromethane / 48 h / 20 °C

6.1: hydrogen / 5% rhodium-on-charcoal / ethyl acetate / 5 h / 1875.19 Torr

7.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / Inert atmosphere

8.1: boron tribromide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

8.2: 0 °C

With N-Bromosuccinimide; hydrogen; bromine; boron tribromide; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5% rhodium-on-charcoal; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 34649-19-9
4,5-dibromo-1H-pyrrole-2-carbonitrile

: 1402652-62-3
C₁₄H₁₁BrN₂O

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave

3.1: 1,2-dimethoxyethane; water / 0.5 h / 120 °C

4.1: Hoveyda-Grubbs catalyst / dichloromethane / 48 h / 20 °C

5.1: hydrogen / 5% rhodium-on-charcoal / ethyl acetate / 5 h / 1875.19 Torr

6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / Inert atmosphere

7.1: boron tribromide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

7.2: 0 °C

With N-Bromosuccinimide; hydrogen; boron tribromide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5% rhodium-on-charcoal; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;