2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol

Base Information

Chemical Name:2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol
CAS No.:850171-14-1
Molecular Formula:C₂₃H₂₅ClN₄O₅S
Molecular Weight:504.994
Hs Code.:

Synonyms:2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol

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Chemical Property of 2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol

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Technology Process of 2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol

There total 5 articles about 2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 73568-25-9
2-chloro-3-quinoline carboxaldehyde

: 615552-65-3
1-(methylsulfonyl)-4-{4-nitro-3-[(trimethylsilyl)methyl]benzyl}piperazine

: 850171-14-1
2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In Isopropyl acetate; for 0.5h;
DOI:10.1021/jo0480545

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 850171-14-1
2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl acetate; aq. ethanol / 0.5 h / 20 °C

2.1: 900 mg / Et₃N / isopropyl acetate / 0.5 h

3.1: tetrahydrofuran / 0.5 h

3.2: 85 percent / I₂ / tetrahydrofuran / 3 h / 20 °C

4.1: 56 percent / tetrabutylammonium fluoride / isopropyl acetate / 0.5 h

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; ethanol; Isopropyl acetate;
DOI:10.1021/jo0480545

Reference yield:

: 55276-43-2
4-methanesulfonylpiperazine

: 850171-14-1
2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / Na₂CO₃ / dimethylformamide / 2 h / 20 °C

2.1: tetrahydrofuran / 0.5 h

2.2: 85 percent / I₂ / tetrahydrofuran / 3 h / 20 °C

3.1: 56 percent / tetrabutylammonium fluoride / isopropyl acetate / 0.5 h

With tetrabutyl ammonium fluoride; sodium carbonate; In tetrahydrofuran; Isopropyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo0480545