615552-65-3Relevant academic research and scientific papers
Synthesis of 5-substituted-1H-indol-2-yl-1H-quinolin-2-ones: A novel class of KDR kinase inhibitors
Kuethe, Jeffrey T.,Wong, Audrey,Qu, Chuanxing,Smitrovich, Jacqueline,Davies, Ian W.,Hughes, David L.
, p. 2555 - 2567 (2007/10/03)
(Chemical Equation Presented) A number of approaches for the synthesis of the 1H-indol-2-yl-1H-quinolin-2-one ring system found in the potent and selective KDR kinase inhibitor 1 are described. The preparation and reaction of trimethylsilylnitrobenzene 26
SUBSTITUTED INDOLES AND A PROCESS FOR PREPARING SUBSTITUTED INDOLES
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Page/Page column 15, (2010/02/10)
The instant invention is directed to novel compounds of Formulae (I) and (II), as wells a process for preparing compounds of Formula (II). The process comprises a palladium-catalyzed reductive cyclization of a compound of Formula (I) to produce a compound of Formula (II).
Synthesis of novel KDR kinase inhibitors through catalytic reductive cyclization of o-nitrobenzylcarbonyl compounds
Wong, Audrey,Kuethe, Jeffrey T.,Davies, Ian W.,Hughes, David L.
, p. 7761 - 7764 (2007/10/03)
An efficient synthesis of o-nitrobenzylcarbonyl compounds is demonstrated through the Swern-type oxidation of readily accessible phenethanol analogues. Reductive cyclization of o-nitrobenzylcarbonyl 3 using catalytic Raney nickel gives 1H-indol-2-yl-1H-qu
Effective strategy for the preparation of indolocarbazole aglycons and glycosides: Total synthesis of tjipanazoles B, D, E, and I
Kuethe, Jeffrey T.,Wong, Audrey,Davies, Ian W.
, p. 3721 - 3723 (2007/10/03)
(Matrix presented) An effective strategy has been developed for the rapid and efficient preparation of ortho-nitrostyrenes, which can be converted to unsymmetrical 2,2′-biindoles. A unique condensation of these 2,2′-biindoles with (dimethylamino)-acetalde
