615552-65-3

Basic information

• Product Name: Piperazine, 1-(methylsulfonyl)-4-[[4-nitro-3-[(trimethylsilyl)methyl]phenyl]methyl]-
• CAS NO: 615552-65-3
• Molecular Formula: C16H27N3O4SSi
• Molecular Weight: 385.56
• Mol File: 615552-65-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(methylsulfonyl)-4-[[4-nitro-3-[(trimethylsilyl)methyl]phenyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(methylsulfonyl)-4-[[4-nitro-3-[(trimethylsilyl)methyl]phenyl]methyl]-(615552-65-3)
• EPA Substance Registry System: Piperazine, 1-(methylsulfonyl)-4-[[4-nitro-3-[(trimethylsilyl)methyl]phenyl]methyl]-(615552-65-3)

Safety Data

• Hazardous Substances Data: 615552-65-3(Hazardous Substances Data)

Upstream product

• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 58198-49-5 1-(4-nitrobenzyl)piperazine 
• 55276-43-2 4-methanesulfonylpiperazine 
• 13170-43-9 (trimethylsilyl)methylmagnesium chloride 
• 423747-61-9 1-(methanesulfonyl)-4-(4-nitrobenzyl)piperazine 

Downstream Products

• 615552-45-9 2-[trans-2-(5-{[4-(methanesulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)vinyl]-1-(phenylsulfonyl)-1H-indole 
• 850171-27-6 1-(2-chloroquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone 
• 850171-48-1 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}-2-chloroquinoline 
• 820976-77-0 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}-2-methoxyquinoline 
• 850171-46-9 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}quinoline 
• 850171-14-1 2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol 
• 863969-66-8 2-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-2-nitro-phenyl]-1-quinolin-3-yl-ethanol 
• 796854-51-8 2-[5-(4-methanesulfonyl-piperazin-1-yl-methyl)-2-nitrophenyl]-1-(2-methoxyquinolin-3-yl)-ethanol 

Relevant articles and documents

SUBSTITUTED INDOLES AND A PROCESS FOR PREPARING SUBSTITUTED INDOLES

The instant invention is directed to novel compounds of Formulae (I) and (II), as wells a process for preparing compounds of Formula (II). The process comprises a palladium-catalyzed reductive cyclization of a compound of Formula (I) to produce a compound of Formula (II).

Synthesis of novel KDR kinase inhibitors through catalytic reductive cyclization of o-nitrobenzylcarbonyl compounds

An efficient synthesis of o-nitrobenzylcarbonyl compounds is demonstrated through the Swern-type oxidation of readily accessible phenethanol analogues. Reductive cyclization of o-nitrobenzylcarbonyl 3 using catalytic Raney nickel gives 1H-indol-2-yl-1H-qu