Technology Process of (3aR,8aS)-benzyl 3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate
There total 5 articles about (3aR,8aS)-benzyl 3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
toluene;
for 4h;
Inert atmosphere;
Reflux;
DOI:10.1021/ol5004109
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3.1: (R)-1,1'-binaphthyl-2,2'-phosphoric acid; C15H17F6N2(1+)*Br2*BF4(1-); 2C15H17F6N2(1+)*3BF4(1-)*Br(1+); sodium carbonate / toluene / 2 h / 0 °C / Inert atmosphere; Enzymatic reaction
4.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 4 h / Inert atmosphere; Reflux
With
2,2'-azobis(isobutyronitrile); C15H17F6N2(1+)*Br2*BF4(1-); 2C15H17F6N2(1+)*3BF4(1-)*Br(1+); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; (R)-1,1'-binaphthyl-2,2'-phosphoric acid; sodium hydride; sodium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/ol5004109
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3.1: (R)-1,1'-binaphthyl-2,2'-phosphoric acid; C15H17F6N2(1+)*Br2*BF4(1-); 2C15H17F6N2(1+)*3BF4(1-)*Br(1+); sodium carbonate / toluene / 2 h / 0 °C / Inert atmosphere; Enzymatic reaction
4.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 4 h / Inert atmosphere; Reflux
With
2,2'-azobis(isobutyronitrile); C15H17F6N2(1+)*Br2*BF4(1-); 2C15H17F6N2(1+)*3BF4(1-)*Br(1+); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; (R)-1,1'-binaphthyl-2,2'-phosphoric acid; sodium hydride; sodium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/ol5004109
![(3aR,8aS)-benzyl 3a-bromo-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate](/Databaselist/images/loading.webp)
