1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Base Information

Chemical Name:1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane
CAS No.:308124-45-0
Molecular Formula:C₅₀H₈₃N₇O₁₅
Molecular Weight:1022.25
Hs Code.:

1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Synonyms:1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

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Chemical Property of 1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

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Technology Process of 1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

There total 9 articles about 1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 122555-91-3
1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

: 308124-43-8
5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

: 308124-45-0
1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Guidance literature:: With caesium carbonate; In acetonitrile; at 40 ℃; for 72h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 308124-45-0
1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

2: 75 percent / H₂ / Pd/C / ethanol; CHCl₃ / 2585.81 - 3102.97 Torr

3: 80 percent / Et₃N / diethyl ether / -20 - 20 °C

4: 73 percent / KI / tetrahydrofuran / 40 °C

5: 31 percent / Cs₂CO₃ / acetonitrile / 48 h / Heating

With dmap; hydrogen; caesium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; acetonitrile; 1: Acylation / 2: Hydrogenation / 3: Acylation / 4: Alkylation / 5: Alkylation;

Reference yield:

: 926231-53-0
2-amino-1-(N-methylcarbamoylmethoxy)benzene

: 308124-45-0
1,4,7-tris(tert-butoxycarbonylmethyl)-10-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / KI; Na₂HPO₄ / acetonitrile / Heating

2: 70 percent / NO₂BF₄ / acetonitrile / -20 - 20 °C

3: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

4: 75 percent / H₂ / Pd/C / ethanol; CHCl₃ / 2585.81 - 3102.97 Torr

5: 80 percent / Et₃N / diethyl ether / -20 - 20 °C

6: 73 percent / KI / tetrahydrofuran / 40 °C

7: 31 percent / Cs₂CO₃ / acetonitrile / 48 h / Heating

With dmap; disodium hydrogenphosphate; nitronium tetrafluoborate; hydrogen; caesium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; acetonitrile; 1: Alkylation / 2: Nitration / 3: Acylation / 4: Hydrogenation / 5: Acylation / 6: Alkylation / 7: Alkylation;